Acetoacetic acid

Acetoacetic acid (formula CH3·CO·CH2COOH) - organic ketoacid; intermediate product of the metabolism of fatty acids and amino acids. The content of acetoacetic acid in the blood (at the rate of 0,3-2 mg%) and daily urine (OK 3-15 mg) increases with starvation, acute febrile processes (particularly common in children) and in severe forms of diabetes mellitus. Introduction of carbohydrates and insulin lowers the content of acetoacetic acid. Cm. also Acetone body.

Acetoacetic acid is an organic compound from group b-ketoacid. Thick liquid; soluble in water, alcohol and ether. In aqueous solutions decomposes when heated to acetone (see) and CO2. The body is formed as an intermediate product of the metabolism of fatty acids and amino acids leucine, phenylalanine, tyrosine and other Number of acetoacetic acid in the blood is 0.3 mg-2% ; the urine out 3-15 mg per day. The content A.K. in the blood and in the urine increases with depletion in the liver carbohydrate reserves (glycogen) due to starvation, acute febrile processes (particularly common in children) and other Very much (up to 6 grams or more per day) isolation A.K. with urine in severe forms of diabetes mellitus. Introduction of carbohydrates and insulin lowers the content of A.K. Presence A.K. in the urine can be recognized by wine-red staining her ferric chloride, disappearing over time [sample Gerhardt (more correctly Gerard)]. Cm. also Acetone body.