Addison's disease

Addison's disease (synonym bronze disease) is a clinical syndrome caused by chronic insufficiency of the adrenal cortex. The reasons of insufficiency of the adrenal cortex are often tuberculosis, primary atrophy of the adrenal glands, amyloidosis, tumors of the adrenal cortex, purulent infection, brucellosis, treatment cytostatic agents (mielosan derived mustard gas). In the basis of the pathogenesis of symptoms when edisonova disease is decreased production of cortisol and aldosterone. With a lack of first bind function disorders of the gastrointestinal tract, the weakness, cardiovascular disorders, low blood sugar on an empty stomach; with deficiency of second - violations of salt exchange, dehydration, hypotension.
Disease progression gradual. At first appear weakness, fatigue, weight loss. Then join the symptoms of the disorder of the function of the digestive tract: nausea, complete lack of appetite, diarrhea, alternating constipation, sometimes severe abdominal pain. Blood pressure significantly reduced. Develops anemia. Addison's diseasethe Most striking symptom of the disease is a bronze color of skin-dependent accumulation of pigment (Fig. 1). It appears mostly on places not covered by clothing (face, neck, hands). Pigmented from the nature of the place (nipples Breasts, genitals, anal folds) painted stronger. Pigmentation is distributed and on the mucous membranes (the soft sky, lips, mucous membrane of the cheeks).
Typical for edisonova disease low sodium and chloride in the blood, and fasting glucose and high content of potassium. The disease is chronic. Complications - suddenly or gradually coming attacks adrenal failure, sometimes leading to coma (see). Forecast significantly improved as a result of application of modern TB and hormonal funds.
Treatment. Therapy for TB (PASK, ftivazide, streptomycin) and hormonal (hydrocortisone, desoxycorticosterone intramuscularly, cortinas subcutaneously or intramuscularly).
Treatment of adrenal coma - see Coma. Nutrition to edisonova disease should be varied, the food must contain a large amount of sodium chloride and a small amount of potassium salts, vitamins appointed in high doses, especially vitamin C (0.4-0.6 g / day). Recommended maximum peace; contraindicated work associated with significant mental and physical tension. Hospitalization is needed during the initial identification of edisonova disease, with severe forms of the disease prone to crises.