Edie syndrome

Edie syndrome (W. J. Adie; synonym: disease Edie, papillotomy syndrome Weyl syndrome Weyl - ray syndrome Kehrer - Edie syndrome Holmes - EDI) - pupillary violations and areflexia on the lower extremities.
Localization of pathologic process, causing the syndrome Edie, its etiology and pathogenesis is not clear. There is an opinion that the syndrome Edie caused by defeat of the following entities: supranuclear paths nuclei III pairs of nerves; nuclei III pairs of nerves; hypothalamus; ciliary site; short, ciliated nerves; sphincter pupil; efferent link arc pupillary response to light. Some authors found syndrome Edie with traumatic brain injury, encephalitis, diabetes, alcoholism, and neurosis. In the literature there are indications of a possible link syndrome Edie with syphilis, deficiency disease or infection. Some authors believe that the syndrome Edie depends on metabolic disorders caused endocrine dysfunction, and first of all by the adrenal insufficiency, others explain the origin of the disease Edie delay acetylcholine because of the weakening of its destruction cholinesterase in mineralnych apparatus of the pupil.
The phenomenon tonic pupil, which consists in a one-sided mydriasis and a very slow decrease, accompanied by the loss of one or more of the tendon reflexes on the feet without the presence of other neurological symptoms. On EDI, tonic pupil - unilateral violation; he wider than normal, often deformed, does not react immediately on the light, slowly expanding in the dark and narrows with light effects and tapering and expands when convergence and accommodation. This pupil enough widens and narrows under the influence of drugs, responds to pain irritation. Sometimes these main features significantly modified.
The severity syndrome EDI is complete and incomplete. He found one, and less often from two sides. In some cases the pupil at unilateral violations is already healthy. Sometimes there is a violation of accommodation, usually blurred vision subjects. In zacapawanyi in the eye gomatropina and ezerin noted oppression parasympathetic pupillary innervation.