Agammaglobulinemia (synonym deficiency syndrome antibodies) -absence or a sharp decrease in the content of gamma globulin in the blood plasma. This reduces or becomes impossible to develop the required number of antibodies, and therefore patients agammaglobulinemia extremely susceptible to infectious diseases. There are hereditary and acquired agammaglobulinemia. Hereditary agammaglobulinemia - a rare disease, often in boys (usually detected in the age up to 6 years); it is connected with the underdevelopment of lymphoid-plasma tissue and the loss of the body the ability to synthesis of gamma-globulin. Acquired agammaglobulinemia common in people of both sexes aged from 7 to 70 years; in some cases the disease is the result of suffering a severe infectious diseases or occurs in malignant tumors of lymphoid apparatus (chronic lymphocytic leukemia and other), nephroses and other Clinically agammaglobulinemia characterized by susceptibility to bacterial infections in normal resistance to viral infections. Infectious disease with agammaglobulinemii flowing long, with frequent exacerbations and severe complications. The diagnosis is by detection of low levels of gamma-globulin during electrophoresis plasma (see Electrophoresis, electrophoretic study). The prognosis is unfavorable. Treatment out under the supervision of a physician: introduction gamma globulin 1 time per month to 0.1 g per 1 kg of body weight intramuscularly; blood transfusion.