Amides (IN-WITH-NH2) connection of the balance of acid (acyl) with the remainder of ammonia (amino group). Amides - crystalline substances, except for formic acid amide (formamide), which is a liquid. In water soluble only low-molecular amides.
The number of A. plays an important biological role.
and glutamine
(amides aspartic and glutamic amino acid) found in large quantities in plants. In the tissues and organs of animals and their content varies widely. This Amida play an important role as a backup and transport of ammonia in the body. The share of glutamine in humans accounts for about 20% of amine nitrogen blood. Amide nitrogen glutamine, acting in the liver, undergoes a series of transformations, which goes into urea. Nitrogen glutamine may also be used for the synthesis of purines. Glutamine is indispensable for the growth of mammalian cells in tissue culture. Asparagine and glutamine are an integral part of many proteins. By leukemia, as well as in patients with schizophrenia and epilepsy glutamine content in blood is increased, gout is reduced.
Splitting asparagine and glutamine in the body begins with dezaminirovanie, resulting in the formation aspartic and glutamic acids, which then undergo certain specific transformations (see Nitrogen metabolism). Asparagine and glutamine can directly, without prior dezaminirovanie, to join the reactions of transamination. The process of transamination glutamine is accompanied by dezaminirovanie, and ammonia is formed from the amide group glutamine. Ammonia is produced in the kidneys in dezaminirovanie glutamine, those who came to him with blood, neutralizes acid, removed from the body with urine.
Amide lipoic acid (Lipaemic): participates as a cofactor in the processes of oxidative decarboxylation pyruvic and II) ketoglutarova acids.
Nicotinic acid amide (nicotinamide) C5H4NCONH2 is part of dinucleotide (NAD) and phosphorus derivative (NADP) - coenzymes many dehydrogenases.
The amide of acetic and propionic acids are part of cobalamin (vitamin B12).