Ankylosing spondylitis

Pages: 1 2 3 4

Ankylosing spondylitis is a severe disease that begins mainly in youth and adulthood, acquires progressive course, sooner leads to immobility (ankylosauria) iliac bone, and intervertebral rib-vertebral joints and to the formation of the so-called bamboo sticks (spine, over time, become completely immobile). After 8-10 years in a process involving the hip and shoulder joints, which greatly reduce the performance of patients; patients become disabled and are unable to serve themselves.
Clinical bases of the doctrine of ankylosing spondylitis and its specific features were developed in 1892, C. M. Bekhterev; he suggested a number of methods of treatment of this disease, and so it bears his name - the Bechterew's disease.
For almost 100 years, there were various scientific Outlook on development mechanism ankylosing process, it was suggested that many of the methods of its treatment. And yet still, this problem is not solved.
It should be emphasized that due to the lack of a unified view about ankylosing spondylitis and methods of early diagnostics of the success of treatment of these patients is low, so the disease is becoming a progressive course and leads to premature disability.
However, recent studies have shown that the detection of early clinical signs of severe illness and systematic use of physical therapy and balneotherapy methods of prevention and treatment sometimes on the background of pharmaceuticals and motor activity allow to slow down the disease process, to weaken the clinical manifestations of the disease and save these patients ability to work.
It is shown that if in rheumatoid arthritis starting mechanism of the disease development is the focal infection of the tonsils, carious teeth etc. when ankylosing spondylitis this infection mainly breeds in the urinary system and the lower intestine, and the infection not only has sensitizing effect on the body, and first of all on the sympathetic border trunks, and immediately blood and lymphatic vessels flagged in the iliac bone joints. On the background of increased sensitivity of cells and tissues, especially synovia and ligaments of the spine, inflammation, leading to the destruction of collagen connective tissue, the emergence gistiotitarnaya, lymphocytic and leukocyte cells, as well as to the development of autoimmune chain reactions by supporting tissues inflammation.
This inflammation occurs in the thickness of the pelvic ring (iliac, pubic and sacral bone), the vertebrae and joints, in particular anatomical and functional units, which jointly determine the stillness of intervertebral and rib-vertebral joints. Inflammation involves hand-ligamentous apparatus of the spine and supported the changes that simultaneously develop adaptive systems of the body, primarily in the pituitary-adrenal and of sympathetic-adrenal.
During sensitization edge of the trunks of the sympathetic nervous system increases the activity of adrenocorticotropic hormone (ACTH), increases the synthesis of 11-oxycorticosteroids and increases the total number of free and bound steroid hormones. The increase in the total number of hormones is essentially defensive in nature, directed against the progression of inflammatory process. This physiological measure of protection leads to decrease, and then to the exhaustion of the adrenal cortex. In addition, further increased thyroid-stimulating function of the thyroid gland, increases hormonal and weakened sympathetic branch of sympathetic-adrenal system. Such complex transformations in the organism determine the pace of development of inflammatory process in rheumatoid arthritis, and ankylosing spondylitis.