Antacid

Antacids drugs that neutralizes the hydrochloric acid in gastric juice. To antacid products include sodium hydrogen, a number of drugs magnesium (magnesium oxide, magnesium a carbonate the basic, magnesium trisilicate), aluminum (aluminium hydroxide), calcium (calcium carbonate primary), alkaline mineral water (see).
The mechanism of action antatsidnykh funds is mainly in the chemical neutralization with hydrochloric acidcontained in the gastric juice. In some antatsidnykh funds (aluminum hydroxide, magnesium trisilicate) plays an important role adsorption acids.
Sodium hydrogen is the most well-known anti-acid agent. Its action is developing rapidly, but the neutralizing force is relatively small. In addition, for the neutralisation of acid the drug results in the release of carbon dioxide, which has a stimulating effect on the receptors gastric mucosa, causing secondary increased secretion. Magnesium oxide as antacids means four times more active than sodium bicarbonate, does not cause the secondary gain secretion. Its effect occurs more slowly. Calcium carbonate is the main activity inferior magnesium oxide. Especially shows the use of long and gently existing antatsidnykh funds - magnesium trisilikata and aluminum hydroxide as the neutralization of the gastric juice should be avoided.
Antacids are used in gastritis and peptic ulcer disease, accompanied by increased acidity gastric juice. Long-term use excessive amounts of sodium bicarbonate may cause alkalosis, accompanied by abdominal pain, nausea, vomiting. Separate antacid - see articles on the titles of certain medications (such as Ammonium chloride, Magnesium, Sodium).

Antacid (gr. anti - against, lat. aciditas - acid) - drugs that neutralizes the hydrochloric acid in gastric juice. To antacid products include sodium bicarbonate (see), a number of drugs magnesium (see) (magnesium oxide, magnesium carbonate the basic, magnesium trisilicate), aluminum (see) (hydrate aluminum oxide, aluminum phosphate), calcium (see) (calcium carbonate primary), alkaline mineral water (see).
The mechanism of action antatsidnykh funds is mainly in the chemical neutralization with hydrochloric acids in the gastric juice. In addition, a significant role in the action series A. S. (hydroxide of aluminum, magnesium trisilicate) plays adsorption of acid.
The application of A. S. the high acidity gastric juice eliminates direct action of hydrochloric acid in the gastric mucosa, liquefies mucus, inhibits the secretion of the pancreas and accelerate the evacuation of stomach contents into the intestines. Alkali, oppressing activity of gastric glands and pancreas, cause a break in their work (vacation), after which comes back to normal.
Sodium bicarbonate is the most well-known anti-acid agent. However, this tool is not suitable for reducing acidity gastric juice. This is because neutralizing force of bicarbonate of sodium is relatively small (1 year neutralizes 120 ml of 0.1 N. Hcl); in addition, by neutralizing acid sodium bicarbonate is the release of carbon dioxide, which has a stimulating effect on receptors gastric mucosa, causing secondary increased secretion. It should also be noted that when receiving sodium bicarbonate, especially in large quantities, are not neutralized bicarbonate content of the duodenum, which under normal conditions neutralized the hydrochloric acid of the gastric contents. Sucking, bicarbonates lead to the creation of alkalosis.
As A. S. sodium bicarbonate is often prescribed along with anticholinergic drugs. With this purpose, you can use the drug bicarbon (Becarbonum), published in tablets, each containing 0.3 g of sodium bicarbonate and 0.01 g extract krasavki. Sodium bicarbonate is combined also with coating, and other absorbent materials. When such combinations increases efficiency and reduces undesirable effect of sodium bicarbonate. To such combination products used at the raised acidity of gastric juice, is vikalin (see).
Magnesium oxide, as antacid means, in comparison with sodium bicarbonate has significant advantages. It is 4 times more active (1 year neutralizes 500 ml of 0.1 H. HCl), does not cause the secondary gain secretion and does not alkalosis. The reason is that magnesium oxide neutralizes hydrochloric acid with the formation of magnesium chloride, which in turn bicarbonate neutralizes the duodenal contents with the formation nevsosavchegosa carbonate magnesium.
Calcium carbonate core is alkalosis, however, activity inferior magnesium oxide (1 year neutralizes 200 ml of 0.1 H. HCl). Valuable A. S. is magnesium trisilicate. In the stomach state becomes a gel which will neutralize and adsorbs hydrochloric acid (1 g trisilikata magnesium neutralizes 155 ml 0.1 N. HCl). He is A. S. long periods.
To reduce the acidity of the gastric juice is used more different drugs aluminium in the form of powders and gels. The most common of them received the hydroxide of aluminum (about 1 g of the drug will neutralize 200-250 ml of 0.1 H. HCl). Antatsidnyi effect oxide hydrate aluminium is mainly based on the adsorption of acid and is prolonged.
At hypersecretion the most appropriate designation A. S. for 30-60 minutes before and after 1-1/2 hours after a meal, as a preliminary reception of alkali reflex inhibits the activity of gastric glands and pancreas, and subsequent neutralizes hydrochloric acid gastric juice, released during the meal.
When applying A. S. avoid the neutralization of the acid gastric juice. In this regard it is expedient to apply A. E. acting soft and long, such as the hydroxide of aluminum, magnesium trisilicate. Hydrate alumina supports the pH of the stomach contents at 3.5-4.0 for 60-80 minutes, and magnesium trisilicate bring the pH of 3.5 to 6.0. The dose of these drugs does not cause increase of pH, and only prolongs the action.
A. S. applied in gastritis and peptic ulcer disease, accompanied by increased acidity gastric juice. Long-term use excessive amounts of sodium bicarbonate may cause alkalosis, accompanied by abdominal pain, nausea, vomiting.