Antibiotics isolated from bacteria

Practical application received a number of antibiotics isolated from bacteria. For example, Escherichia coli was received pyocyanin (Pardos, Derkach). Currently, the drug is called Sonatina received in synthetic form. Sarasin find application mainly in surgical practice in the form of a local application.
Among antibiotics isolated from bacilli important place tyrothricin (dub) and gramicidin S (G. F. Gause and M., Brazhnikov).
Tyrothricin and gramicidin To inhibit the growth of staphylococci and streptococci and good help with angina and suppurative processes, killing pathogens of these diseases. Gramicidin a release capsules in the form of 2% alcohol solution that before use, dilute with water to 100 times and local applied in the form of poloskani, irrigation, lotions, etc.
From hay Bacillus received subtilin and bacitracin, active against Staphylococcus and Streptococcus spp.
Bacitracin is used as a local agent for the treatment of suppurative processes and is used in combination with other antibiotics, the action of which it increases.
Polymyxin applies only locally and through the mouth, as in intramuscular it causes changes in the kidneys. The local application of low toxicity. Polymyxin operates mainly against gram-negative bacteria, particularly pathogenic races E. coli, it is especially effective against Pseudomonas aeruginosa, which is resistant to other antibiotics. Polymyxin used when introducing processes caused by the Association of germs, with Escherichia coli, in particular in the treatment slowly healing wounds, abscesses, carbuncles, furuncles, gidradenit, piodermitah, ulcers, burns II and III extent with suppurations.
The local application antibiotic does not give pain, reduce discharge from the Russian Academy of Sciences that allows you to do more rare ligation. Local applied in the form of 1% solution or 0.1% ointment. In the treatment of purulent otitis polymyxin used as drops. When administered polymyxin not absorbed from the gastrointestinal tract and may not have toxic effect on the organism. Therefore, they treat some intestinal infections, and in combination with neomycin used to prepare patients during operations on the gastrointestinal tract.