Antithyroid tools

Antithyroid funds (synonym tireostaticeski funds) - drugs inhibiting the biosynthesis of hormones the thyroid gland and providing specific therapeutic effect with hyperthyroidism - thyrotoxicosis. To tools include antithyroid Blazin, diyodtirosina, radioactive iodine, merkazolil, thiuragyl, potassium perchlorate. Antithyroid properties have some natural substances, in particular those contained in cabbage, turnips. Action antithyroid funds due either to the inhibition of the enzyme systems, involved in the oxidation of iodine in iodine and in the processes of inclusion iodine molecule of thyroid hormones (thiuragyl and merkazolil)or braking ability of the thyroid gland accumulate iodine, essential for the formation of hormones (perchlorate potassium). Antithyroid funds do not affect the hormones of the thyroid gland that already circulate in the blood, so the symptoms of thyrotoxicosis - tachycardia, increased metabolic rate, sweating, etc., - faint not at once, but some time after the application of antithyroid funds. After the disappearance of symptoms of hyperthyroidism dose antithyroid funds reduce to support, which is given within several months to a year or more. Reduced levels of thyroid hormones leads to increased production in the anterior lobe of the pituitary thyroid-stimulating hormone, under whose influence the thyroid gland hypertrophies - sobolinoe action antithyroid funds. After the termination of the introduction of antithyroid funds hypertrophy disappears. To prevent zabojnogo actions antithyroid funds prescribed drugs iodine, diyodtirosina, betain that inhibit the secretion tireotroponogo pituitary hormone. In addition to hyperthyroidism, antithyroid funds designated also in preparing the patient for surgery, removal of the thyroid gland to address acute symptoms of thyrotoxicosis that impair prognosis in surgery. Side effects when using antithyroid funds (skin itching, dermatitis, urticaria, headache, increased body temperature) are rare. In some cases, there may be lakopenia, neutropenia, agranulozitos, so in the treatment of antithyroid means necessary to make repeated blood tests. Separate antithyroid funds - see articles on the names of products (for example, Bethann, Merkazolil and others).

Antithyroid funds (synonym tireostaticeski drugs) - drugs used to treat diseases associated with hyperthyroidism. Antithyroid means block the biosynthesis of hormones the thyroid gland and cause an increase in its size (sobolinoe action)that is a secondary reaction. Antithyroid properties have many natural substances, including those contained in cabbage, turnips, and other plants, and synthetic drugs: paraaminosalicilovaya acid, sulfanilamida, thiocyanate connection, etc. Used with the medical purpose antithyroid funds belong mainly to two groups: 1) thiouracil and its derivatives; in the USSR became widespread 6-methyl-2-thiouracil (see Thiuragyl); 2) imidazole derivatives; in the Soviet Union used 1-methyl-2-mercaptoimidazole (see Merkazolil). In addition, the therapeutic use find some compounds that are not related to these groups, in the USSR - potassium perchlorate (see).
The blockade of the biosynthesis of hormones the thyroid gland caused, as I suppose, by the suppression of antithyroid means of enzyme systems, with the activity of which is connected oxidation of iodide compounds and the inclusion of the iodine molecule of thyroid hormones. On already formed and circulating in the blood thyroid hormones antithyroid tools do not. Therefore the manifestation of therapeutic effect precedes latent period, the duration of which depends on the dose A. S., the degree of hyperthyroidism and individual features of the patient. The blockade of gormonoobrazovanii accompanied by redness, swelling, hyperplasia and hypertrophy of the thyroid gland. This"sobolinoe"("stromynke") action A. S. is a secondary effect, associated with improving tireotroponogo pituitary function. Zebegeny effect A. S. reversible upon cessation of their introduction hyperemia and hypertrophy cancer undergo reverse development. To prevent or mitigate zabojnogo actions antithyroid time prescribed small doses of iodine preparations.
The removal of symptoms of hyperthyroidism in the treatment of A. S. occurs in a certain sequence. First of all disappear tachycardia and other cardiovascular disorders, reduced basal metabolism, decreased functional disorders of the Central and autonomic nervous system. Later comes the weight gain. Slowest be adjusted eye symptoms.
Antithyroid tools can be used as the primary method of treatment, and in preparing the patient for thyroidectomy or treatment of radioactive iodine (see Iodine). When applying A. S. as the main method initially appointed high ("shock") dose to resolve the main symptoms of thyrotoxicosis and the onset of euthyroid state, then reduce the dose to support the achieved a therapeutic effect. The total duration of treatment: several months to a year or more. Premature dose reduction, treatment interruptions or early termination of his frequent causes of failure in achieving a permanent cure. Curing many patients leads to permanent cure sustainable euthyroid state after stopping treatment. Therapy antithyroid means often leads to permanent cure in the diffuse structure toxic goiter. In nodular and diffuse-nodular forms toxic goiter A. C. it should not be used as the main method of treatment. In such cases, they are used for preoperative preparation (as with diffuse toxic goiter, if shown strumectomy), assigning them in high doses up expressed easing symptoms of hyperthyroidism, which takes usually 1-2 months. 2-3 weeks before the surgery the patient logoiski solution or a solution of potassium iodide to reduce the sloppiness of the fabric of goiter, vascularization and bleeding during surgery.
Toxic reactions caused by A. S. observed not often. These include itching, dermatitis, urticaria, headache, fever. In some cases, there may be leukopenia, neutropenia, agranulocytosis, and therefore the treatment A. S. is under constant control over a condition of the blood.