Artusa phenomenon

Artusa phenomenon (M Arthus) - local anaphylactic reaction that occurs when multiple subcutaneous introduction of protein. For the first time was observed at the injection rabbits horse serum. Redness and swelling usually appear after the fourth injection of protein, enhanced during subsequent introductions and end with necrosis at 6-7-second injection. Originally giperergicakie inflammation gradually acquires hemorrhagic character. The phenomenon artusa you can call not only actively (as described), but passively,i.e., the animal has received pre serum another animal of the same species, sensitised foreign protein. The mechanism of the phenomenon artusa based on the interaction of antigen with the antibody. Cm. also Allergy, Anaphylaxis, Serum sickness.