Aureomycin (Aureomycinum; synonym: aureomycin, biomitsin, Tuominen, chlortetracycline, And-377) is a broad-spectrum antibiotic. Refers to a group of tetracycline (see). Received by the Daggar (Century Duggar) in 1948 from the culture fluid Streptomyces aureofaciens And-377. Recently, from the producer of aureomycin were received new products: bromine-tetracycline, dimethylchlorosilane and other
Aureomycin - crystalline substance of Golden color (hence the name - from lat. aurum - gold). Mol. weight - 478,7, temperature PL 168-169 degrees, the solubility of 0.5 mg/ml at temperature of 25 degrees. In medical practice is applied hydrochloric salt of aureomycin - stable formulation do not lose activity (at room temperature) 24-36 months, solubility of which is considerably higher and amounts to 13 mg/ml Aqueous solutions A. significantly less stable than the dry preparation. Biological activity of A. measured in units of activity: 1 unit of biological activity corresponds to 1 mcg chemically pure reason.
A. retards the growth of gram-positive and gram-negative bacteria, spirohet, protozoa, Rickettsia, and major viruses. Rapidly absorbed from the gastrointestinal tract, obnarujivaesh in serum within 30 minutes - 1 hour from the moment of application per os; the maximum concentration of aureomycin is defined in 2 hours; then the level of antibiotic decreases, but remains in therapeutic concentrations for 6-8 hours. The highest concentration is determined A. in the gastrointestinal tract, bile and liver. Therapeutic concentrations A. are also created in saliva, blood, ascitic fluid and prostatic juice. In the cerebrospinal fluid A. penetrates poorly.
Aureomycin used in the treatment of patients with pneumonia of various etiology, subacute septic endocarditis, scarlet fever, bacillary and amoebic dysentery, gonorrhea, brucellosis, tularemia, ricketsiosis, spotted fever, trachoma, fever. Daily dose of the drug with the introduction of per os varies from 0.1 to 0.2 g 5-6 times a day and depends on the nature and severity of infection; treatment 6-8-10 days. The most frequent complications are: nausea, vomiting, diarrhea, stomatitis, proctitis; rarely allergic reactions and superinfection (staphylococcal enteritis, candidiasis). With the introduction of aureomycin in large doses can be complications of the liver. A limitation to the use of drug - increased sensitivity of the individual patient. Cm. also Antibiotics.