Protein hydrolysates

Protein hydrolysates - products from the breakdown of proteins used for parenteral nutrition. They are well absorbed by the body, are full product parenteral nutrition in different conditions involving protein deficiency, reduce the phenomena of intoxication. Protein hydrolysates not cause severe anaphylactoid reactions.
In medical practice, use the following protein hydrolysates:
Hydrolysis (Hydrolysinum) is derived from proteins in the blood of cattle. Dosage form: capsules and hermetically sealed bottles of 250 and 500 ml maintained at a temperature of 4-6 degrees. Similar gidralazina the drug, derived from homogeneous blood, is called "aminotropin".
Hydrolyzed casein (Hydrolysatum caseini) - product of the acid hydrolysis of casein. Dosage form: capsules 250 ml, bottles of 200 and 400 ml maintained at a temperature of 10-23 degrees.
Aminopeptidase (Aminopeptidum) - made from proteins in the blood of cattle. Dosage form: capsules of 250 ml or bottles of 250, 300 and 500 ml Keep at room temperature.
Protein hydrolysates are applied in cases involving protein deficiency, and, if necessary, reinforced protein nutrition (with the depletion of the body, including the gastrointestinal diseases, poisoning, burn disease, radiation sickness), as well as the impossibility of food through the mouth (after operations on the esophagus, the stomach). Protein hydrolysates enter only drip intravenous and subcutaneous doses up to 2 litres per day. Enter slowly (20 drops per 1 min). If no reaction (sometimes red person, sensation of heat, difficulty breathing) a speed of up to 40-60 drops per 1 MPN. During the whole period of the need to monitor patients.
Protein hydrolysates contraindicated in cardiac decompensation activities, haemorrhage in the brain, throm, the acute and nephrosis nephrosclerosis.
Sometimes when using protein hydrolysates can be observed adverse reactions: nausea, vomiting, fever, itching of the skin, urticaria. In these cases shows the use of Dimedrol (1 ml of 1% solution intramuscularly or intravenously), calcium chloride (intravenous 5-10 ml 10% solution). Cm. also Blood fluid.

Protein hydrolysates products hydrolytic cleavage of proteins used for injecting the body for therapeutic purposes. In the process of obtaining protein hydrolysates protein is cleaved to short di - and tripeptides chains and individual amino acids, losing its specific properties, primary toxicity and anaphylactogenic. Protein hydrolysates are extracted from animal blood or protein of milk (casein), using acidic, alkaline or enzymatic hydrolysis. The greatest distribution in the Soviet Union received three Baltic, manufactured in industrial conditions,- hydrolysis (L 103), hydrolyzed casein and aminoatil.
Hydrolysis (L 103) receive from the blood serum of cattle, whole blood or blood clots. Hydrolysis is hydrochloric acid at boiling point; to remove acid is used ion-exchange resin; the finished product is sterile filtered and bottled in bottles. Contains: 0.7 - 0.9 g% nitrogen and a set of salts present in the blood plasma.
Casein hydrolysate (COLIC) receive boiling casein with sulfuric acid; destruction of sulfate ions is achieved by the use of ion-exchange resins; ready hydrolyzed sterile filtered and bottled in bottles, can withstand hot sterilization. Contains: nitrogen 0.70 to 0.95 g%, amino nitrogen 35-45 g %and chloride salts of sodium, potassium, calcium and magnesium in amounts of their concentration in blood plasma.
Aminoatil is prepared from the blood of cattle by hydrolysis of the enzyme pancreatic cancer. For maintenance of common and amino nitrogen and salts it is similar to that described protein hydrolyzate.
In addition to these drugs, blood clots, remaining after harvesting blood serum of donors, prepare aminotropin; hydrolysis is conducted with the help of hydrochloric acid. Abroad produce B., mainly from casein: in the USA - Amihan, in Sweden - aminosol, in England - Cathedral and other
Protein hydrolysates - effective drugs for parenteral protein nutrition; they are well absorbed by the body when intravenous and subcutaneous administration, restore nitrogen balance, which leads to an increase in the protein content in the blood plasma. Application of protein hydrolysates shown in all cases, when no normal food through the mouth, diseases, accompanied by the development of protein deficiency, and are caused by the loss in weight, slow wound healing, reduced resistance to infections, human liver and kidneys, in preparation for the operation and in postoperative period, burns, poisoning, peptic ulcer disease. To combat shock uses protein hydrolysates - blood substitutes type dextran (poliglyukin), and for detoxification - drugs polyvinylpyrrolidone (gemodez).
Protein hydrolysates enter the drip method - intravenous, subcutaneous doses up to 2 litres per day. B. was released without glucose and glucose, increasing their efficiency; adding vitamin B12 also helps to improve understanding B. G.; B. efficiency, can be enhanced by the addition of alcohol, fat emulsion and so on, the Speed of introduction: 20-70 drops of a 1 minutes; by increasing the speed may have nausea, urticaria, headache; in these cases transfusion stop for a few minutes, and then resume, but at a slower rate.
Contraindications: cardiac decompensation, bleeding in the brain, throm, the acute and nephrosis nephrosclerosis.
The form of release, B. - vials 450-500; the period of storage-5 years.
Cm. also Blood fluid.