Besedki method - a method desensitization, necessarily used to prevent anaphylactic reactions (see Anaphylaxis) with injections antimicrobial and antitoxic treatment-and-prophylactic sera: injected subcutaneously in the beginning of 0.1-0.3 ml serum, and through 1 - 2 hours rest of the dose.
Besedki methods (A. M. Besedka) - methods desensitization, oral vaccination, immunization with live sensitised vaccines, which have found application in specific prophylaxis and therapy of infectious diseases.
The most common method desensitization used to prevent anaphylactic reactions (see Anaphylaxis) when imposing preventive or therapeutic purposes antitoxic, antibiotic or antiviral heterogeneous sera (obtained from a horse or other animal). Re-introduction of such sera may cause serum sickness (see), or anaphylactic shock. Desensitization on Besedke necessary and when introduced into the body healing serum treated by different methods from ballast substances. It is known that individuals with a heightened sensitivity to protein fractions antitoxic serum (diphtheria, tetanus and others), respond to their introduction severe symptoms of shock. When desensitization on Besedke first enter a small amount (0.1 ml of serum is administered subcutaneously, and then 1-2 hours - the rest of the dose.
The second method of Besedki - method of oral vaccination is applied against intestinal infections and is based on the concept of Besedki about the so-called local immune system (see Immunity). According to Besedki, immunity oral immunization against intestinal infections is acquired due to immunization sensitive tissue or organ (for example, intestines with dysentery) and natural resistance of other tissues and organs. For oral immunization against intestinal infections, Besedka proposed dry vaccine in the form of tablets (three days in a row, on 1 table., contains 100 billion killed microbes). For better absorption of antigen produced sensitization bowel bullish bile. A method not has received a wide circulation.
The third method proposed by Bezrodnoy,- active immunization against typhoid and dysentery live vaccines, sensitised specific immune serum. However, these vaccines are not tested in a wide epidemiological experience and not spread in the practice of inoculation against typhoid fever. Cm. also Immunization.