Bicillin (Bicillinum; SYN.: benzatin-penicillin, diaminobenzidin, peridural, Tardelli) is an antibiotic obtained by connecting the two moles of benzylpenicillin with one mole N, N1-dibenzylethylenediamine (bicillin-1). Due to the large value of the molecule B. almost insoluble in water, when mixed with which it forms a thin resistant polymer. In this regard, in the body is created depot penicillin, for a long time arriving in blood. B. little toxic and possesses antihistaminic activity. B. it is used for prevention and treatment of infectious diseases caused by susceptible to penicillin pathogens (Streptococcus, Staphylococcus and Streptococcus pneumoniae), and also for the treatment of syphilis. Due to prolonged effect of the Baltic widely used for the prevention and treatment of rheumatism. Contraindications to the use B. is increased sensitivity to penicillin.
Bicillin is available in 3 dosage forms: bicillin -1 (B-1); bicillin -2 (B-2), which is a mixture of 300 000 UNIT B-1 and 100 000 IU potassium or sodium salt of penicillin; bicillin-3 (B-3), containing 100 000 IU potassium, procaine and etilendiaminom salts benzylpenicillin. Enter bicillin only intramuscularly. B-1 is used in doses of 300 or 600 000 000 UNITS 1 week or 1 200 000 IU 2 times a month for adults; children B-1 enter 1 time a week estimated 5,000 - 10,000 IU per 1 kg of weight or 20,000 UNITS per 1 kg weight 2 times a month. B-2 is used once a week at a dose of 400 000-800 000 UNITS or 2 times per month at a dose of 1 600 000 IU for adults; children at the rate of 7500-15 000 UNITS per 1 kg of weight per week or 26 000 E L on 1 kg of body weight 2 times a month. B-3 is administered to adults in doses of 300 000 UNITS, re-injection made on the 4th day. At a dose of 600 000 UNIT B-3 is administered every 6 days.
Bicillin is produced in glass vials containing 300 000 and 600 000 or 1 200 000 IU. B. must be stored in hermetically corked bottles at a temperature of no higher than 20 degrees.