Biologically active substances

Biologically active substances (copper, iron). Determination of biologically active substances is not a test of functional state of the liver, but may be important for differential diagnosis and prognosis of certain diseases. Here you should indicate the value of determination of serum iron and copper.
Definition of iron and copper * blood presents some challenges, and published methods give different standards for the content of these elements.
Copper is found in the serum mainly in the form of a complex with the A2-globulin - mediakidz (ceruloplasmin). The number of mediakidz increases in infectious hepatitis, accordingly, to increase the activity of other enzymes (aldolase, transaminases), and in most cases reflects the severity of the disease. The most significant increase in copper in the blood during mechanical jaundice, which is connected with the delay in the allocation of copper as a result of violations of the outflow of bile. This fact can be used in the diagnosis of obstructive jaundice. The amount of iron in the serum of patients with disease Hungary increased to a greater extent than the amount of copper. Hyperthermia due to a violation of its liberation from the depot - liver. When mechanical jaundice number of serum iron increased slightly.
Differential diagnostic value is the mapping of the content of iron and copper in serum with defining relations copper/iron. This factor in any method of determining elements is 0.8-0.9. At Botkin's disease coefficient is reduced to 0.7, with mechanical jaundice increases to 1.2 (A. F. of Bluger, 1964; L. A. Maksimov, and So I Stricter, 1963; Butzengeiger, Lange, 1952; Laudahn, 1954).

* Methodology see: A. F. of Bluger. Structure and function of the liver at epidemic: hepatitis. Riga, 1964.