Blastomogenic action of ionizing radiation

The ability of some radiation agents to cause cancer was first established clinical observations.
Experimental receive Acting in animals using radioactive radiation began with induction-ray view of sarcomas in rats. Then experimentally was called x-cancer rabbit on the skin of the ear and skin cancer in mice. Further malignant Acting in animals were called and radium (sarcomas in rats, sarcomas and carcinomas in Guinea pigs, sarcoma of the bone in rabbits). Experimental tumors in rats and mice can be called ultraviolet rays and prolonged sun exposure, and carcinogenic is acting a certain part of the ultraviolet spectrum.
Introduction under the skin, and various internal organs (kidneys, liver, egg, and so on) open handsets radium preparations or yarns impregnated with salts of radium, caused in rats, mice and Guinea pigs various malignancies, but only 10-20% of the cattle, and over long periods (up to 30 months).
Introduction into the peritoneal cavity or under the skin of rats from 0.5 to 5 ml thorotrast (colloidal drug thorium oxide) calls sarcoma on the injection of a substance approximately 50% of cases through 9-17 months. Subcutaneous administration of thorotrast mice, rabbits, Guinea pigs also causes sarcoma.
In several countries (Austria, France, Czechoslovakia) as a contrast agent for x-ray examination of internal organs, particularly the liver and kidneys, applied thorotrast that is deposited in the cells of the reticuloendothelial system of these bodies; 15 to 18 years after its introduction was observed various malignant tumors.
By direct injection of radioactive substances in the bones (and in some cases and the introduction of a carcinogenic chemical substances) was the first experimentally to get malignant Acting in monkeys (N. N. Petrov al.).
Introduction to the body of radioactive substances, in particular the number of isotopes that can cause different tumours in various organs and first of all in those where it is deposited radioactive substances. In this regard, there are hepatotropic, osteo, lymphotropic isotopes, etc., the same isotope can cause various O. different authorities depending on a way of his introduction and Deposit in the body. Blastomogenic effective is the part of radiant energy that is absorbed by tissue. O. may develop in the irradiated part of the fabric depending on irradiation conditions. When external exposure may occur skin cancer and very rarely O. internal organs. Internal exposure occurs with the introduction of radioactive substances in the body. This tumors can develop in those organs where deposited radioactive substances and damaged tissue. Leukemia, O. endocrine and mammary glands takes all radioactive isotopes regardless of the characteristics of their distribution and excretion from the body. Often they can also arise from external exposure.