Large allergic syndromes in the clinic

Preliminary notes

Although when exposed to an allergen on the body sensitization are all cells and tissues, it is well known that the clinical manifestations of Allergy marked only on the part of certain organs and tissues. This is because of an allergic reaction of some tissues in the body remain clinically "silent". For example, sensitization striated muscles is just as smooth. Striated muscle not only lock the antibodies, but when you contact them with a specific allergen release histamine. In General we can say that in allergic reactions striated muscles release more of histamine than the smooth muscles of the bronchi. However, the effects of histamine on the smooth muscles of the bronchi occurs bronhospazm (kinks in bronchial asthma)and receptors poperechnopolostah muscles are not sensitive to the action of histamine. In anaphylactic reactions role of striated muscle is practically reduced to zero.
It is known that in anaphylactic reactions can be involved organs and tissues, which themselves do not release histamine. It turns out that histamine, released by cells of striated muscles, the blood is transferred to the distance and affects other organs (bronchi, vessels, gastrointestinal tract, etc. it Should be noted that the source of histamine - fat cells are distributed b the body unevenly. So, in Guinea pigs them most in the bronchi, the uterus, the digestive tract, in rats - in the skin, the mesentery and vascular walls.
Clearly, fabrics, containing more histamine, are affected in allergic reactions more difficult. This theoretical position is important: it explains the presence of those or other syndromes and also in some degree, the varying sensitivity of the various bodies to the effect antigistaminnah drugs.
In the clinic there are different allergic diseases: hay fever, allergic year-round rinomate, asthma and eczema, urticaria and anaphylaxis, hemopathy and migraines, thyroiditis, etc. All these different allergic diseases are common immunological mechanism.
Clinicians have long noticed that many of these syndromes may coexist in the same patient or to replace each other. Historical data also show that the combination or the alternation of these syndromes include the patient and his relatives in the ascending and descending lines.
As a result of immunological studies have established that the cause of allergic diseases one - interaction between specific antigen and immune factor (antibody), fixed on the cells. In allergic syndromes, which are based on allergic reactions and immediate and delayed type, these antibodies are fixed on the cells.
It should be noted that the sensitization of the organism does not mean the disease ("barrel of gunpowder not yet exploded!"). For occurrence of clinical manifestations of sensitization of the body with the necessary reaction between specific antigen and sensitized cells. Clinical manifestations of Allergy is the result of the release of biologically active substances which are endogenous toxins to the body.
Almost all tissues can be a place, where three allergic reactions (this explains the polymorphism of clinical manifestations of Allergy). This skin: urticaria, swelling Kwinke, eczema, erythema multiforme, purpura; respiratory tract: allergic rhinitis, sinuitis, bronchial asthma; abdominal allergic syndromes, reminiscent of the clinic of acute abdomen and require immediate surgical intervention (gastritis, colitis, pancreatitis).
Drug allergies has polymorphic clinic, including heavy defeat of vessels and blood-forming organs. The defeat of the liver, kidney, uterus, pancreas and bladder, joints, Central and peripheral nervous system, endocrine glands, the eyes may have allergic nature.
In this book we can't give the description of all these clinical syndromes and do not stop the disease, well-lit in many monographs.

  • Atopic syndromes
  • How are allergic diseases
  • Shock body
  • Immunological aspects
  • Allergic rhinitis. Bronchial asthma
  • Urticaria, dermographism and angioedema
  • Exudative diathesis and atopic dermatitis
  • Anaphylactic shock
  • Serum sickness
  • Drug Allergy
  • Contact dermatitis