Bowen disease

Bowen's diseaseBowen disease - precancerous skin. Some authors consider Bowen's disease as vnutriepetelialnaya squamous cell carcinoma of the skin (the basal layer is stored, no cell invasion, unlike the true cancer). Observed more often in the elderly. Usually has the form of a single reddish plaque, consisting of fused flat papules, poorly infiltrated and wrong, but clear boundaries, usually covered with scales or crusts. The lesion is slowly growing on the periphery, often izyaslavs in the center. Bowen's disease, usually localized on the face, back, on the genitals. To differentiate Bowen's disease, you keratomas senile (see), arsenic - keratosis, psoriasis (see).
Treatment: radical surgical excision, close-focus radiotherapy. Cm. also the Precancer.

Bowen disease (J. T. Bowen) - vnutriepetelialnaya epithelioma, carcinoma in situ. Described by Bowen as precancerous skin. It occurs in both sexes middle-aged or older on almost any area of the skin, mostly on the torso. Appears brownish-reddish spotted nodular education, which, increasing becomes a plaque irregular shapes with eroded or covered with scales and crusts surface [printing. table, figure 2]. Plaques often solitary. Many years later can turn into invasive cancer.
Histologically - thickening of the epidermis, hyperkeratosis, parakeratosis and, most significantly, the election disruption subulate layer of cells which lose the usual form and become sharply polymorphic (Fig). Appear single, less often large multi-core epithelial cells with giant hyperchromic cores; many mitoses. The individual cells of the epidermis coarsen (diskeratoz). In the underlying connective tissue - inflammatory infiltrate with a predominance of lymphoid and plasma cells. Differential diagnostics is carried out with psoriasis, senile keratosis, basal cell carcinoma.
Treatment: radiotherapy, deleting entities by surgery or a combination of both methods. Cm. also Precancer.

Pronounced polymorphism of cells subulate layer.