Research methods of carcinoid

Routine clinical study of peripheral blood and urine in patients with carcinoid any localization did not indicate any significant deviations from the norm. Waldenstrom (1958) indicates that at long distance in some patients, the urine is red due to the presence of the substances indolului nature.
The most reliable signs of a functioning carcinoid are the increase of the content of 5-hydroxytryptamine (5-GOTH) in the blood and 5-hydroxyindole-acetic acid (5-GOIC) in the urine. The latter figure may be specified in any of the biochemical laboratory method Udenfriend (1955). Serotonin is determined using fluorometer with high sensitivity. The increase in the concentration of 5-GOOK in the urine within 100-1000 mg / day is reliable diagnostic criterion of the disease. In most cases, the high figures 5-GOOK observed in metastatic carcinoid, but theoretically similar changes in this indicator could meet and when the primary tumor large sizes without metastasis.
X-ray examination of the chest size of the heart are often unaugmented, and its configuration is not different from normal. Fluoroscopy gastrointestinal tract rarely is essential for diagnosis, since the carcinoid does not usually change the path of the wall and the relief of the mucous membrane of the affected organs (the tumor is in the submucosal layer). Carcinoids of the stomach are the exception to this rule (see above). X-ray examination is of secondary importance for recognition of intestinal obstruction.
When carcinoids of the stomach and colon justified the use of gastro - or, fibreboard and rectoscopy.
With the increase in the liver certain diagnostic role of needle liver biopsy with subsequent histological and histochemical study of this material. Ludin and others (1966) offer for the diagnosis of metastasis of carcinoma in the liver to use visceral arteriography.