Chlorothiazide (Chlorthiazidum; list B) is a diuretic; 6-chloro-7-sulfonyl-1, 2, 4-benzotiadiazin-1,1-dioxide.
Diuretic effect of chlorothiazide accompanied by an increased excretion of sodium, chloride, to a lesser extent, potassium and bicarbonate.
Apply chlorothiazide edema associated with heart and kidney failure, cirrhosis of the liver, toxicosis of pregnancy, latency, salt and water in the body in the treatment of ACTH and corticosteroid drugs. Chlorothiazide also reduces blood pressure and increases therapeutic effect of other antihypertensive drugs.
Appoint chlorothiazide inside tablets to 0.5 g 1-4 times a day depending on the severity of the disease. When applying chlorothiazide in connection with the possible development gipokaliemii recommend a diet rich in potassium salt, or the appointment of potassium chloride. Chlorothiazide contraindicated in heavy progressive forms of renal failure. With the advent of more effective drugs of this group (dihlotiazid, tsiklometiazid) chlorothiazide almost lost its meaning.
Cm. also Diuretics.