Climacteric neurosis and ways of its non-hormonal treatment

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In 1961 in the work Kushima, Kamio, Ocuda were given extremely interesting information verifying the primacy of age-related changes in the hypothalamus. The authors, using the method of transplantation of ovarian and hypophysis from old rats young and Vice versa, came to the conclusion that the process of ageing begins earlier in the hypothalamic region, and then apply to the pituitary gland and the ovaries. Thus, it was established that under menopause you should understand the involutionary process, primarily in developing higher gipotalamicakih centres and manifested diverse autonomic and endocrine functional changes. That is why the clinical manifestations of both normal and pathological menopause is so diverse and cover a variety of aspects of life of the organism.
Recognizing fully opinion expressed above, we consider it appropriate to mention another important General biological moment. Its essence is based on the fact that due to the involutionary realignment of hypothalamic regulation of a number of vegetative functions and glands disturbed primary homeostasis of the organism, which, in turn, requires the normalization of and adaptation to new emerging conditions of existence; meanwhile adaptation undertaken by hormonal function (adrenal gland and nervous system, largely depend on the mobility of higher nervous centers, their ability to normalize reactions and the intention to establish the relative level of physiological rest (equilibrium), without which the long existence of the organism is impossible. Therefore there is a necessity to study the magnitude of mobility nerve centers (unstable) during normal and pathological manifestations of menopause.
This work by using special electrophysiological techniques was conducted (S. N. Davydov, 1963). It turned out that the level lability higher brain centres varies among women of reproductive, menopause, menopause and senile periods. Thus, the level of instability in the reproductive period of high, normal menopause reduced, mainly due to the weakening of the braking process, in late menopause he rises again, and when entering into old age declined as a result of the weak excitation and by the weakening of braking.
In pathological course of menopause there has been a sharp decline in the lability. This phenomenon is so constant that can serve as a criterion of severity climax - the more heavily on its clinical manifestations flows menopause, the greater the decline lability noted in patients.
The nature of this condition, perhaps in part depends on what at menopause, in addition to the above-noted increased activity of the autonomic and endocrine centers, there is a significant activation of the reticular formation of the brain. The proof is similar provisions can be seen in the significant increase of the level lability, defined using the function electroencephalography with the use of chlorpromazine - substances, sharply inhibitory activity reticular formation (S. N. Davydov, 1963). All this allows to modify slightly the definition of menopause.
Menopause is adaptation syndrome in relation to the changing conditions of existence of the organism, occurring due to primary age of involutional processes in the hypothalamus and the second changes the function of peripheral endocrine glands, metabolism, mobility of nervous processes and aimed at restoring the physiological balance of the organism on a new level.