Climacteric neurosis and ways of its non-hormonal treatment

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Successes in treatment of climacteric neurosis explains the success of General biology and endocrinology in relation to the understanding of the essence of the process.
One of the first theories as to the onset of menopause and its painful manifestations, is based on the fact that the primary are changes in ovarian function. "Loss" of ovarian function as the main cause of menopause was recognized by numerous researchers. However, clinical observations refuted this provision facts about the development of climacteric neurosis in the period of full or partial preservation of the normal menstrual cycle (S. N. Astakhov, 1941; Hawkinson, 1938, and others)that, according to Century, Baranova (1961) and C. M. of Dillman (1969), common in 51.8% of women. Studies O. N. Savchenko (1967) found that in the first two years of menopause in women is allocated to 69 mcg of estrogen, whereas in women of reproductive age in the normal secretion of estrogen varies 20-126 mcg. Thus, these data showed that during menopause there are no significant lowering of estrogen. O. N. Savchenko also determined that the total amount of estrogen in women with painless for menopause and when expressed its pathology is in the same range. The ratio between active and inactive fractions of estrogen during menopause is about the same as in the reproductive period.
Colpocytology data also revealed no parallelism between the value of the reaction of the vaginal epithelium and clinical symptoms of menopause (Yu Century Dreizin, 1950). Herrmann (1957) indicates that the phenomenon of pathological climacteric more common in cases where Cytology pattern indicated sufficient estrogenic potential.
Thus, numerous and versatile researches have shown, that, despite existing in menopause, change of ovarian function, it is not of primary and leading to help explain all the variety of climacteric disorders.
In the period of time when it was revealed the special role of the pituitary gland in the regulation of the sexual cycle, have been carried out to study the functions of this body at menopause. Already the first works Zondek (1938) identified three phases in the relationship between the pituitary gland and the ovaries at menopause: a) pelivalikoima, during which increases the amount of estrogen because of the lack of luteinizing pituitary function; b) oligodactylia characterized by low FSH - pituitary function, and reduce the allocation of estrogen ovaries; C) polyendocrine accompanied by the accumulation of large quantities of FSH. Leading change, leading to climacteric disorders, admitted changes in the second and third phases. However, a number of researchers (Heller and Heller, 1939, and others) these data were not confirmed. So, for example, M. L. Khesin (1949) could not identify parallelism between the nature of manifestations of climacteric neurosis and number of gonadotropins. G. S. Stepanov (1967) examined 12 women with preserved menstrual cycle and 81 woman in menopause from a few months to forty years. It was found that the total number of gonadotropins released in women with long-term menopause, no trends or to further increase, nor decrease. It was found also that there is no dependence between the character of the flow of climacteric neurosis and number of gonadotropins. These data have shown that those women who had for many years as menopause, the function of the pituitary remains the same as it was in early menopause, i.e. in the period when it was possible to assume continuing menopause.
Thus, accumulation of facts contradicted put forward the theory of the primacy of violation of gonadotropic function of the pituitary gland in the development of the menopause, although the changes are pituitary function, with a corresponding impact on the ovaries at menopause is unmistakable.
In the early fifties the works of C. G. Baranov and his staff was grounded theory, according to which the primary changes that lead to deviations in the function of the pituitary ovarian, should be considered when menopause involutional changes in the hypothalamus. C. M. Gilman, J. D. Rafalski (1961), O. N. Savchenko and G. S. Stepanov (1964) concluded that the signs of the involutionary realignment of the hypothalamus is loss of cyclical effects on the pituitary gland in respect of the gonads and the manifestation of hyperactivity of a number of exchange, vasomotor and endocrine its centers. Proof of this are the increase in blood pressure, weight gain, body, manifestations of gipertireoidizmom, increase of carbohydrate, fat and protein metabolism, a violation of napochechnikov, i.e., signs, clearly showing their dependence on centers of the hypothalamus.