For, complications of Crohn's disease

Crohn's disease refers to diseases with very diverse clinical symptoms and kind of flow. It refers to a chronic, slowly progressive disease. Typically lesions of the intestine are strictly localized in nature and rarely spread throughout the length of the digestive canal. The progression of the disease occurs more often in place of the primary lesion of the intestine, where growing cicatricial changes, there is a narrowing of the lumen of the intestine, there are phenomena of intestinal obstruction. Older people Crohn's disease runs a less hard, with more rare than in younger individuals, the recurrences.
Mac-Cardy (1963) for 6 years have traced the fate of 64 patients with Crohn's disease. Of these, 54% worked successfully, 23% were practically healthy, 13% needed hospital treatment, 8,8% - died. In successful cases, conservative or surgical treatment of patients long time to feel able-bodied people.
Should specifically consider acute forms of Crohn's disease. Last clinically indistinguishable from acute appendicitis, and such people do in the surgical Department, where they undergo surgery. Crohn (1949) believed that in 25% of cases of acute ileit precedes the chronic phase of the disease. However, more recent studies have found that it is not (Bockus, 1964; Bayless, 1968). Obviously, should be attributed to acute form of the disease only those cases where, on the background of significant signs of Crohn's disease is an acute inflammation and swelling of the ileum. In other cases, acute ility should be treated as a separate nosological form with different etiological factors (dysentery, allergies, lymphadenitis). Gump and others (1968) have traced the fate of 24 patients with acute form of Crohn's disease, and only one of them was later developed chronic form of the disease. Apparently, "acute" in many cases can be attributed to the first clinical manifestations of hidden flowing chronic forms of Crohn's disease.
The literature describes 41 cases of perforation of the intestine affected by Crohn's disease (Nasr and others, 1969). Usually a perforation occurs in areas located proximal to the narrowing of the lumen of the intestine. This complication occurs more often at the height of exacerbation, and transmural the pattern of damage to the bowel, undoubtedly, contributes to its perforation.
One of the rare but dangerous complications of Crohn's disease is a cancer of the intestine. In literature in 1970 described only 20 cases of adenocarcinoma in the background granulomatous lesions of the small intestine. However, it should be taken into account that cancers of the small intestine are rare forms of pathology and their frequency is only 0,0024%. At the same time Bockus (1964) leads materials Amman, where among 5,000 cases of Crohn's disease, published in the world literature, set the frequency of cancer of the small intestine, is equal to 0.08%, and among 174 137 autopsies in other diseases he was only 0,048%. Apparently, Crohn's disease of the small intestine refers to the optional pre-cancerous diseases, especially among young people.
Much more difficult addressed the issue of combination granulomatous colitis and colon cancer. It is known that the latter is often a complication of ulcerative colitis. This is due to deep degenerative and inflammatory changes of the epithelial elements of the mucosa of the colon in this disease, as in Crohn's disease in the most affected submucosal layer and the lymph system. Colon cancer is often encountered in clinical practice and combining it with Crohn's disease can be either a coincidence or the result of the individual predilection to both of these diseases (Jones, 1969). This is the meaning of the existence of different localizations of a cancer and granulomatous changes in the colon at the same patient. Lifetime cancer detection on the background of the long-existing granulomatous lesions is often insurmountable difficulties and is sectional godsend.