Cyclophosphamide

Cyclophosphamide (Cyclophosphanum; synonym Endoxan; list a) - antineoplastic. Applied with chlamydia, lymphosarcoma, retikulosarkome, multiple myeloma, chronic lymphocytic leukemia, and with lung cancer, breast cancer, ovarian cancer, bladder and other designated cyclophosphamide intramuscularly or intravenously 0.2 g (10 ml of 2% solution) 2-3 times a day, the course of treatment is from 4 to 14, you Can also assign inside, intraperitoneally and vnutriplevralno. Higher doses in Vienna and intramuscularly: single 0.3 g daily - 0,6,
Cyclophosphamide is contraindicated in severe radiation (less than 2500 of cells in 1 mm3 the blood), thrombocytopenia (less than 100,000 in 1 mm3 the blood), anemia, cachexia, severe liver disease and kidney failure, terminal stage of the disease.
Method of production of platinum: answers to 0.05 g and sterile powder in sealed bottles of 0.1 and 0.2 g
Cm. also Antitumor agents.

Cyclophosphamide (Cvclophosphanum; synonym: Endoxan, Cyclophosphamidum, Cytoxan; list a) - cancer treatment; cyclic ether N, N-di-(2-chloroethyl)- N'-oxypropylated phosphoric acid. Itself is inactive, but in the body (primarily in the liver) is transformed into an active form. The experimental data, relatively little toxic, but is characterized by a large accumulation of action. It has a wide range of antitumor activity. Provides clinical effect with chlamydia, chronic lymphoblastic, acute leukemia, lymphoreticulosis, cancer of the ovary, breast, lung and other malignant tumors.
Use intravenous cyclophosphamide in three schemes: 1) daily 200-400 mg total dose 4-12 g, 2) 0.5 to 0.6 g daily for one week and 3) once for 1,5 - C g with repeat 3-4 weeks. Side effect is bone marrow suppression, which, however, quickly restored, despite the deep leukopenia. Thrombocytopenia expressed little.
Cyclophosphamide is one of the most widely used currently therapy of chemotherapy drugs. The relative safety of application, an opportunity of introduction of large doses with large gaps make it convenient in practice, including outpatient. Can be used inside in pills. Method of production: sterile powder in vials of 0.1 and 0.2 g, pills or tablets of 0.05 g Cm. also Antitumor agents.