Cycloserine

Cycloserine (Cycloserinum; synonym Novoserin; list B) - TB drug II series. Also active in respect of gram-positive and gramotritsatel-governmental microbes. Applied for the treatment of chronic forms of TB in cases when fixed assets no longer exist. Assign inside the food on 0.25 g 3 times a day; with good endurance in the same dose 4 times a day. Prolonged treatment - up to 8 months and more. Cycloserine can cause headaches, dizziness, insomnia, anxiety, irritability, memory loss, paresthesia, peripheral neuritis, fear, hallucinations, seizures epileptiformnye, loss of consciousness.
Cycloserine is contraindicated in organic diseases Central nervous system, epilepsy, mental disorders. Form: tablets : 0.25, store in a dry dark place at temperature not above 20 deg.
Cm. also anti-Tuberculosis drugs.

Cycloserine (Cycloserine; synonym: closin, examining, orientalizing, seromycin, parmesean, ticlopidin, D-4-amino-C-isoxazoline) is a broad-spectrum antibiotic used in the treatment of tuberculosis, particularly in cases where the disease is not responsive to curative treatment other anti-TB drugs.
In experiments in vitro he acts on gram-negative and gram-positive bacteria. Djbn against Rickettsia or fungi. Cycloserine has good activity against mycobacteria in General and of Mycobacterium tuberculosis in particular. Bacteriostatic action of cycloserine for virulent strains of Mycobacterium tuberculosis is evident in the concentration of 5-10 mcg/ml Cycloserine there are strains resistant to other anti-TB drugs. Addictive microorganisms to ticlauserino slow. The use of cycloserine and isoniazid, PASK, streptomycin, digidrostreptomitsinom intensifies its activity against Mycobacterium tuberculosis.
Entering into cycloserine easily absorbed and rapidly enters the body. Therapeutic concentration is created in the serum of a person after 3-4 hours after the introduction and continuing for 12 to 24 hours. More than half of the antibiotic is excreted in the urine. The greatest effect is expressed in cases of prolonged antibiotic therapy (not less than 6 months). Daily dose of cycloserine when administered 0.5-1 g (0.25 g - once).
The use of cycloserine often produces a severe complications of the Central nervous system: convulsive seizures epileptoidnye type, and tonic clonic convulsions, myoclonia, headaches, symptoms polyneuritis. In addition, they can be marked with various mental disorders.
The occurrence of adverse reactions associated with the dosage. Some authors recommend cycloserine dose of 0.25 g 2 times per day. To prevent increased excitability of Central nervous system and the treatment it is recommended to use sedatives. Cm. also Antibiotics.