Dose

Dose (doses) is the number you enter in the body of medications. In the recipe (see) Dose indicated in grams, ounces, biological units (ED) or antitoxic units (AE). Dose at one time is called a single dose (increasing the dose of pro dosi), and the dose received during the day,- day (increasing the dose of pro die). From the dose depends on the concentration of medicinal substance in blood, and hence the intensity of its pharmacologic actions and to a certain extent, speed of onset and duration of effect. The lowest dose that provide pharmacological characteristic reaction is called the minimum valid; the lowest dose that causes toxic effects, - the minimum toxic. Are used for therapeutic purposes dose lying in the interval between the minimum in force and minimal toxic. In order to avoid poisoning for poisonous and drastic substances in Pharmacopoeia (see) are the highest single and daily doses that may not be exceeded in the absence of special indications. To exceed the dose is the right of a doctor. For medicinal substances capable of koumoulirovati (see Accumulation), have a value of dose rate, i.e. the total number of the drug for the entire course of treatment. Therapeutic doses are not permanent, they depend on the individual sensitivity of the patient to medicinal substance, the nature of the disease and other Children are more sensitive to drugs than adults. Higher doses for adults and children of different age are shown in table (see Annex III to the fact). For persons over 60 years of age the dose reduced to 3/4 to 1/2 the usual adult dose.
The dose depends on the method of drug administration: intravenous it in 3-5 times, and in subcutaneous - in 2-3 times less than the dose used inside (through the mouth)when the substance is absorbed slowly.