ECHO-viruses

ECHO viruses are enteric viruses person. Are small RNA-containing viruses that are part of a group of picorna viruses. The types of ECHO-viruses can cause disease in humans: aseptic meningitis, with fever, diarrhea, gastroenteritis, respiratory infections , etc.

ECHO-viruses (enteric cytopathogenic human orphan viruses - intestinal cytopathic orphan human viruses) is a group of small, containing RNA virus belonging to the family of picornaviruses (genus Echovirus). Called "orphan"as a long time remained unknown to their role in human pathology. Isolated from the human intestine in the study of polio by Robbins (F. Bobbins, 1951) and others, Miller J. Melnick, 1952) and other currently known 33 independent serological groups that represent numbers from echo-1 to echo-33. Serial numbering ECHO-virus is conditional, because the researchers were able to conduct a more reasoned differentiation between them and find the features that were previously overlooked. Serotype echo-8 was similar to the echo virus-1 and is now classified as a virus echo-1. Echo-10 has some significant differences from other viruses in this group and are therefore classified as reovirusa and echo-28 included in the group of rhinoviruses.
Virions are in the form of Exedra and cubic type of packing of capsomeres. Their sizes range from 10 to 30 MMK. ECHO viruses are well preserved in 50% glycerin and at low temperatures, resistant to fluctuations in pH (3,0-9,0), chloroform, ether and dezoksiholatom. At temperature 50 degrees destroyed during 30 minutes at temperature 18-20 degree Celsius saved from 1 to 7 days. ECHO-viruses 3, 6, 7, 11, 12, 13, 19, 20 and 21st types cause hemagglutination of human erythrocytes 0 group.
All ECHO-viruses multiply and cause cytopathic effect when the infection is primary tripinsurance crops human kidney and rhesus monkeys, cynomolgus and the green monkey. Most serological types ECHO-virus sensitive culture amniotic cells of the person. The identification of sensitive crops, form and size of plaques and hemagglutinins activities allowed to subdivide ECHO-virus on a number of stable subgroups.
A characteristic property ECHO viruses is their pathogenicity for mice, which after infection develop myositis, and paralysis. Infection also susceptible monkeys, cynomolgus and chimpanzees. The types of ECHO-viruses can cause disease in humans - fever, exanthema, encephalitis, aseptic meningitis, gastroenteritis, lesions of the respiratory tract and other
At selection ECHO-virus as vaccinated material used spinal fluid, from throat swabs and faeces. Excerpted material infect sensitive tissue culture. To identify used RAC, the neutralization and delays of haemagglutination.
Diagnostic value is identifying growth titer of antibodies in patients in the study paired sera. As differential test is also suggested to use an antimetabolite 5-bromosuccinimide, which does not affect the reproduction of RNA-containing viruses, but inhibits the reproduction of DNA-containing. Cm. also the Virus, Enterovirus diseases (enteroviruses).