Pathologic anatomy eclampsia

In eclampsia the mother observed in the liver characterized by hemorrhage mainly under the capsule in the form of "landkarten" spots. Less frequently under the capsule detected light yellow areas of necrosis. In the context of liver motley - hemorrhage, necrosis centers (sometimes with the undeniable eclampsia the liver is not changed). Microscopically revealed accumulation of leukocytes, hyaline and coagulation of blood clots in small vessels, disconnecktie liver cells, reasonable fatty degeneration and necrosis mainly on the periphery of the slices with the deposition (later) salts of calcium.
The brain of small subarachnoid, intracerebral hemorrhages, expressed swelling. Microscopically can be observed thrombosis, perivascular foci of necrosis, with the "ring" hemorrhages, perivascular, pericellular and diffuse swelling, and dystrophic changes of nerve cells; later fibrinoid necrosis vessels (rarely) and the proliferation of glia.
Kidney find swelling basal membrane vessels clubockov and dystrophic changes of tubular epithelium. In rare cases, eclampsia can occur total necrosis of the crust of the kidneys, combined with thrombosis of the branches of the renal arteries. On a cut it is that the bark is permeated large infectobesity sites limited by a red stripe (redness, bleeding from the brain substance. In the lungs is often observed embolism-syncytium Vorsin, whole Vorsin, megakaryocytes, liver cells, as well as swelling and haemorrhages. The blood is dark with a large number of clots, which indirectly proves the increased blood coagulation. The spleen is enlarged. Lymph nodes are large and full. In the mucous membrane of the stomach and intestines are often observed hemorrhages and erosion, in serous cover - hemorrhage. The adrenal cortex poor lipids, in the pituitary gland increased formation and breakup of the basophilic cells.
In placenta often find dark red, spongy areas, seals rounded, caused by the increase in CVS due to their sharp hyperemia, with compression of the relevant parts majorsince space. Syncytium closely located Vorsin, not washed by maternal blood, atrophies or, on the contrary, have proliferated with education "syncytial kidneys." Sometimes there hemorrhage in the interstitium (3. F. Drobina). Formed retroplatsentarno bruises indicating premature detachment of the placenta. Thus on maternal its surface are detected blood clots, in the recent cases of separated easily, and with longer duration - with difficulty, and in the placenta found deepening corresponding form the hematoma. In vessels disappearing shells are lipoids intima plasma soaking and fibrinoid necrosis walls.
The fruit of 10.6% (I. L. Guryanov) is stillborn, often premature. At showdown is often discovered pattern characteristic of intrauterine asphyxia of any nature; rarely in the liver are bleeding, resembling those of the mother. Can be observed and early neonatal death, often due to non-fatal intrauterine asphyxia aspiration of amniotic fluid and subsequent secondary newborn asphyxia or pneumonia, genetically connected with aspiration.