Indirect stimulation of the hypothalamus-pituitary region

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In 1964, Toth and Gimes reported positive results of treatment of amenorrhea in women using elektrovojvodina diencephalic region, and thus inaugurated the use of the known data obtained in the experiment, at the sick people. These authors when bitemporal imposition of electrodes used impulse current with voltage from 9 to 15 V and an amperage from 3 to 6 mA. The procedures were carried out 2 times a week. Of the 24 patients at 20 as a result of treatment has come a General improvement of health and recovered menstruation, in three patients came pregnancy, and 1 patient was received effect of hormone therapy, which was not observed before.
About the possibility to influence the process of ovulation by summing up the electrical impulses directly to the nuclei of the hypothalamus there are reports of a number of experimenters. So, Critchlow (1957, 1958) caused ovulation animals through electrical stimulation arched and ventromedial of medium nuclei of the hypothalamus that he explains the influence of the factor that enhances the secretion of luteinizing hormone from the pituitary. Electrical stimulation of these nuclei conducted Barraclough, Gorski (1961), gave the opportunity to renew ovulation in androgenzawisimah rats that also was associated with increased allocations from adenogipofiza luteinizing hormone. Below, we present additional data digest of literature on the impact of elektrorazpredelenie different parts of the brain on the reproductive cycle.
Confirmation of the idea that such an effect cannot be explained by the influence only on the area of the hypothalamus and pituitary, may serve the data of a number of experiments. So, Kubo and Kawakami (1971), using animals methodology implanted electrodes, investigated the effect of electrical stimulation of the median preoptions zone of basal hypothalamus and the hippocampus on sexual cycle of white rats. It turned out that the initiation of the first two zones leads to stimulation of activity in the hippocampus, and the excitement of the last - to the suppression of basal hypothalamus and mid preoptions zone with changes in sexual cycles of animals. In another paper from the same laboratory (Terasawa, Kimura, Kawakami, 1971) for electrical stimulation of the hippocampus (rectangular pulses with a frequency of 100 Hz for 30 min at inclusion of electrodes 30 with an interval of 30 s) indicated that this effect leads to the suppression of allocation of LH and at the same time contributes to the increase of the LTH. Marschall, Verney in 1936 found that diffuse electric irritation of the brain cause ovulation in rabbits, consequently, increases the impact of luteinizing hormone from the pituitary.
Irritation olfactory cortex weak induction current is observed in female rats increased frequency and lengthening of heat (A. S. breslavskiy, 1956) and ovulation (Sawyer, 1958). Irritation of the alternating electric current zone anterior hypothalamus (between preoptions and bupropionsee areas) is accompanied by a rats a slower onset of estrus, ovulation and education fresh yellow bodies, therefore, enhances the secretion of LH. Even in those cases, when a spontaneous selection LH from the pituitary blocked phenobarbitalum anesthesia, rats can cause the onset of ovulation, producing mild electrical stimulation through the electrode, introduced in preoptions zone of the anterior hypothalamus (Everett, 1964). This phenomenon can be associated with the fact that emerging nervous irritation on neurons reaches the mesial Eminence, in the last released RF - LH that comes in the portal blood and being transported in a adenogipofiza, activates the secretion of LH.
Irritation of the medial eminencia immediately induce ovulation by increasing the outflow of progestins on ovarian Vienna.
Electric irritation almond kernels finanzpolitische system causes female rabbits ovulation (Jamada, 1961), and in the ovary is enhanced pre-ovulatory synthesis progestin (Hayard, Hilliard, Sawyer, 1964). Almond-shaped complex stimulates the secretion of both LH and FSH. Similar irritation girus cinguli is increased allocation of vasopressin and oxytocin, which probably leads to a hemostatic effect.
C. M. Strugatsky and L. R. Avetisova (1969) with good effect applied electrical stimulation diencephalic region in girls with secondary hypothalamic amenorrhea. Used bitemporal the location of the electrodes that, according to the authors, to act through a branch of the trigeminal nerve to increase the tone of the pituitary gland.
C. I. Bodyagina, M. L. Crimea, C. M. the Strugatsky (1972) reported 35 women with clear signs of disturbances of the hypothalamic-pituitary system and secondary amenorrhea, which was treated with the pulsed low frequency current applied to the temporal areas. All patients noted improvement in the General condition, 19 there was increasing function of the ovaries, and 9 established a two-phase cycle and 3 pregnancy.