Eosinophilia

Eosinophilia is the increase in the number of eosinophils in the blood. Under eosinophilia understand increase of eosinophils in leukocyte formula above 5% and in absolute numbers above 320 1 mm3 blood.
Eosinophilia in most cases is a manifestation of allergic reactions sensitized body. It is found in bronchial asthma, serum sickness, hives, inflammation eosinophilic infiltration in the lung, heart, stomach and other organs (Leffler syndrome), helminthic invasions, itching dermatoses, eosinophilic the granuloma bones, intolerance to certain medications, as well as with chlamydia, in the period of recovery from infectious diseases and other kids Have so-called infectious eosinophilia, proceeding with a high fever, enlarged liver and spleen, high content of cells and eosinophils in the blood. The disease takes a long time, ends with the recovery.
In severe infections eosinophils in the blood may be missing (aneosinophilia).

Eosinophilia - increase in blood in the number of eosinophilic white blood cells. Normal eosinophils is 2-4% of the total number of leukocytes
or 50-320 1 mm3 blood. There are small eosinophilia (10%), moderate (up to 20%) and high (over 20%). However, the number of eosinophils better be judged not by percentage and in absolute number, which can be calculated on the basis of interest, but rather when counting the counting chamber at a dilution of blood fluid Dungern or Hinkelman. Eosinophilia in the vast majority of cases of allergic reactions sensitized body.
The increase in the number of eosinophils in allergic processes associated with their role troubleshoot these toxic products. They have the ability to destroy as alien proteins and histamine and carry these substances and their degradation products from crowded places, reducing tensions allergic reactions. In addition, eosinophils are involved in the formation of antibodies and have phagocytic properties.
In the first place (frequency) among the causes of eosinophilia are parasitic, mainly helminthic diseases. Eosinophilia accompanies mainly those worms in which the parasite temporarily (if you are migrating larvae) or resides in the tissues. The first group includes the roundworm, hookworm, strongiloidoz; the second - trichinosis, opisthorchiasis, fascioliasis, Echinococcus, filariasis and other Intensity of eosinophilia may be different; it is particularly high happens when trichinosis and opisthorchiasis, reaching 20-40, sometimes even 75% at high overall leukocytosis. When parasites living in the intestine lumen (pinworm, vlasoglav, tsepni), eosinophilia may be small or absent. From other parasites cause of eosinophilia may be lamblia and ameba. The second largest group of eozinofilia are separatornyi allergic diseases: bronchial asthma, serum sickness, swelling Kwinke, urticaria, membranous colitis, leverovsky volatile pulmonary infiltration, etc., These processes are in most cases are accompanied by moderate eosinophilia. Joining them medication medicine, observed in people with intolerance to certain medications. From the latter the most frequent cause of eosinophilia are antibiotics (penicillin, streptomycin and other), sulfa drugs, drugs arsenic, gold. In the period of treatment of malignant anaemia raw liver and products from it has often been a significant eosinophilia that expired after the drug. Eosinophilia occur in a number itchy dermatitis (eczema, psoriasis, herpes zoster, neurodermit and others).
Some infectious diseases (tuberculosis, syphilis, scarlet fever, epidemic hepatitis)in the pathogenesis of which is involved the allergic component, also often accompanied by moderate eosinophilia. In the period of recovery from certain infectious diseases appears transient eosinophilia, which, in this case favorable symptom. Eosinophilia occur and some collagenoses - rheumatism, nodular the nodosa, scleroderma, dermatomyositis. At the same time, such collagenoses, as rheumatoid arthritis and systemic lupus erythematosus, in most cases, are not accompanied by eosinophilia. Meets eosinophilia and cancer: relatively rare in sarcoma and epithelioma, often with chlamydia, however, eosinophils in the blood when the latter is usually much less than in the tissue of granulomas.
The above eosinophilia are secondary. The cause of them sensitization or other still unknown factor. Primary eosinophilia is in chronic myeloid leukemia, where it is often combined with the increasing number of basophils. This eosinophilic-basophilic the Association is an important diagnostic symptom myeloid leukemia, especially leikemicakih its forms. Rarer form of the disease - eosinophilic leukemia, in which blood is found not only increased 40% or more) number of eosinophils, but immature and sometimes ugly form of these cells. The bone marrow hyperplasia eosinophilic elements with the rejuvenation of them; in the spleen, liver and other organs - eosinophilic metaplasia.
In addition eosinophilia of blood, defined as total eosinophilia, there are eosinophilia local characterized by an accumulation of eosinophilic cells in one way or another organ or tissue. These include eosinophilic infiltration in the lungs, heart and other organs mucous membrane of the bronchi, bronchial asthma, the intestinal mucosa with membranous colitis, i.e., as a rule, at the place where the meeting antigen to antibody and played an allergic reaction.
To establish the causes of eosinophilia important carefully assembled history, repeated, sometimes multiple studies Kala, x-ray examination of the thorax, sometimes sternal puncture.
Because eosinophilia is not a disease, but a symptom, occurring in various diseases, it disappears after successful treatment of the underlying process. These are deworming with parasitic eosinophilia, removal of the allergen (if it is possible to install), the abolition of the calling sensitisation of the drug and, finally, General desencibilizirutuyu therapy (Dimedrol, pipolfen, prednisolone, calcium, hyposulphite). Therapy eosinophilic leukemia same as usual chronic myeloid leukemia.