Erythroblastosis jet

Erythroblastosis jet - proliferation erythroblasts outside of the bone marrow, resulting in infants in response to various influences. In most cases, except erythroblastes, there has been a proliferation of myeloblasts and plasmic order has been revealed, and therefore more accurate to speak about a jet malariarelated. Leading clinical symptom jet erythroblastosis is or that the degree of anemia (see). However, the reactive erythroblasts considered not as a compensatory process that occurs in response to anemia, and as an expression of immune changes the body of a young child, in response to various influences.
In children under one year in the bone marrow in the norm there is a clear predominance of immature blood cells over Mature cells of red and white series. This results in a high lability blood system, which is revealed in various pathological conditions in the form of jet erythroblastosis or malariarelated.
Currently a number of reasons, which leads to reactive erythroblasts: 1) group AB0-incompatibility and Rh incompatibility between the blood of the mother and fetus; 2) infectious diseases, viral (generalized cytomegalovirus), bacterial, staphylococcal sepsis), parasitic (toxoplasmosis, congenital syphilis); 3) a severe form of rickets; 4) the deficit of power (in particular, vitamin B12 deficiency);
Distinguish between heavy and light forms of jet erythroblastosis. Severe reactive erythroblastosis are rare cases in which the reaction of the blood-forming tissue out in the clinic of the first plan and simulates the primary disease of the blood system. This so-called syndrome of Yaksha-Hayama observed more often in heavy rickets or nutritional deficiency. Described cases of the syndrome of Yaksha - Hayama and infectious diseases (generalized cytomegaly).
To simple forms include increased frequency of cases in which changes in blood-forming tissue is moderate and are starting phase syndrome Yaksha-Hayama, not developing or because of an underlying condition that caused the reaction of the blood-forming tissues, stopped, or because the patient is a child dies from intercurrent illness.
Postmortem jet erythroblasts is reflected in the rejuvenation of blood in the bone marrow, the emergence of hotbeds of proliferation of hematopoietic cells in the liver, spleen, lymph nodes, perinephral tissues, sometimes in the lungs. In these pockets of extramedullary hematopoiesis is dominated by the cells of the red Rostock, sometimes even with the presence of megaloblastov (return to embryonic blood); there are also cells of neutrophilic number with a large number of eosinophilic plasmic order has been revealed.
In severe forms of jet erythroblastosis is expressed weight gain spleen (8-10 times), the liver, the increase in lymph nodes. Spleen in the context of juicy, the follicles are not distinguishable, lymph nodes too sappy, the cut-white-red. Bone marrow sternum, vertebral, diaphysis thigh red, sometimes with grey shade, juicy, with pressure - pasty.
In milder forms of jet erythroblastosis noticeable increase in the weight of the authorities is not observed. The pockets of extramedullary hematopoiesis find histological examination.
Severe reactive erythroblastosis must be differentiated with congenital leukemia leukemia and early childhood. The intensity of cell infiltrates, monotony, immaturity, with predominance of white Rostock, the presence of tumor growths in organs and tissues (kidney, liver, skin, gastrointestinal tract), expressed haemorrhagic syndrome, sharp degree of osteoporosis allow to diagnose leukemia (see). The main reference point for differential diagnosis is the presence of a pathological process leading to the development of reactive erythroblastosis.
The treatment should be aimed at eliminating the underlying disease. In mild cases of jet erythroblastosis with the liquidation of the main disease all phenomena of the haematopoietic tissue all cropped. In severe cases, death may occur.