Erythromycin

Erythromycin (Erythromycinum; synonym: Ermycin, Erythran; list B) is an antibiotic, effective against gram of bacteria (streptococci, pneumococci, staphylococci , and others), as well as microorganisms that have become resistant to penicillin and other antibiotics.
Apply erythromycin for the treatment of pneumonia, pneumophilia, scarlet fever, erysipelas, sepsis, meningitis , ear infections, sore throats, tonsillitis, laryngitis, carbuncles, urethritis, wound infections, acute inflammatory diseases of the biliary tract. Is inwards at meal times in the 0.1-0.25 g 4-6 times a day. Higher doses of erythromycin: single 0.5 g daily, 2 G. the Course of treatment is 5-10 days. Side effects (nausea, vomiting, diarrhea, weakness) are rare.
The form of release: tablets 0.1 g (100 000 UNITS) and 0.25 g (250,000 U). Keep in a dry, protected from light place at the temperature not above 20 deg.
Cm. also Antibiotics.

Of new antibiotics, won acclaim for treating clinicians should be mentioned first of all about the erythromycin. In its antimicrobial spectrum erythromycin close to penicillin, but erythromycin effective in cases, when the causative agent of the disease, in particular aureus that is resistant to all previously used to antibiotics, penicillin, streptomycin, tetracyclines, chloramphenicol, bacitracin.
Antibiotic entering through the mouth. It is rapidly absorbed, and after an hour in the blood is found concentrations of the antibiotic that inhibits the growth of microbes.
Erythromycin having a positive effect in the fight against carriers of diphtheria. With the success of it is used for treatment of pneumonia, sepsis, osteomyelitis, boils, angina, faces and pustular skin diseases.

Erythromycin (Erythromycinum; synonymous with ilotycin) is an antibiotic of macrolide group, received in 1952 Mac-Gere (J. M. MC Guire) and TCS. from cultural liquid St. erythreus. Like other antibiotics in this group [oleandomitin (see), carbonized, spiramycin (see) and others], has a spectrum of antibacterial action, close to the action of penicillin (see). Inhibits the growth of many gram-positive bacteria (staphylococci, streptococci, pneumococci, the anthrax Bacillus, Clostridium, Corynebacterium diphtheria) and some gram-negative bacteria (gonorrhea, meningococci, Brucella, sticks pertussis), protozoa (with E. histolytica, Trichomonas vaginalis), Rickettsia, and major viruses (limfogranulema and meningomyelocele mice); active against strains resistant to penicillin.
Erythromycin - base, poorly soluble in water; it dissolves in alcohol, chloroform and acetone. Salt erythromycin with mineral and organic acids are easily dissolved in water.
Erythromycin rapidly absorbed from the intestine. When administered 0.5 g reaches bacteriostatic concentration in human blood after 1 hour and keeps it during 6-7 hours.
Erythromycin is low toxicity. A dose of 1.5-2.0 g (1 000-2 500 000 000 IU) per day patients usually well tolerated, although sometimes diarrhea different intensity, nausea, vomiting, dizziness and stomach cramps. The drug is erythromycin used into 100 000-250 000 UNITS at the reception. The maximum daily dose for adults - 2 000 000 IU. Children up to 5 years appoint 5 000 - 8 000 IU per 1 kg of body weight every 4-6 hours.
Available in tablets (100 000 and 250 000 UNITS). The complex Sol laurislietavietis (erythromycin-estolate; synonym Ilosone) once inside creates a higher concentration of the antibiotic in the blood than the corresponding doses of erythromycin. However, in some cases, especially when used within 14 days or more, this drug can cause jaundice and functional changes cholestatic liver type. Cm. also Antibiotics.