Accesiblity

Esthesioneuroblastoma (from the Greek. aisthesis - sensation) is a rare tumor, gistogematicheskie associated with the olfactory nerve receptors. First described Berger (L. Berger, 1924).
Accesiblity is localized mainly in the nose, often in the maxillary sinus and area chair. It occurs mostly in young age. The tumor grows slowly, can recur; sometimes there has been a rapid growth with the destruction of the surrounding tissue (ethmoid sinuses, orbit, the base of the brain) and metastasis (lymph nodes, lungs, bones and other). Sometimes noted the difficulty in nasal breathing, nasal bleeding, anosmia.
Macroscopically, the tumor is a hilly site soft consistency, the cut grayish-pink color, sometimes with the foci of necrosis. Microscopically distinguish esthesioneuroblastoma, esthesioneuroblastoma and esthesioneuroblastoma. Esthesioneuroblastoma consists of small uniform cells with rounded dark cores and a small number of cytoplasm. Between cells is kinoferria substance (beams neurofibril). The tumor is reminiscent of undifferentiated small cell lung cancer or retikulosarkoma. Esthesioneuroblastoma close to esthesioneuroblastoma, but is characterized by the presence of pseudorosette observed in sympathetic neuroblastoma. Cellular elements bigger than esthesioneuroblastoma, and sometimes grouped in the form of rounded clusters, located in edematous stroma. Esthesioneuroblastoma has true outlets, characteristic for neuroepithelial.
The correlation between the composition of accesiblity and the clinical course is not observed. In most malignant tumors find a large number of mitoses, foci of necrosis.
Treatment of accesiblity complex: surgical removal and subsequent x - ray or radiation. In most cases, the tumor is amenable to therapy.