Aureus: some facts of the biography

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Staphylococcus studied long (L, Pasteur 1879, PU Rosenbach 1884). Under the microscope Staphylococcus have the appearance of clusters of balls in the form of grapes Golden or lemon color.
Between pathogenic (capable of causing disease) and non-pathogenic Staphylococcus, there are a number of transitional stages. It is important to note that the recent significant changes of the biological properties of staphylococci under the influence of antibacterial drugs complicate the differentiation of pathogenic from non-pathogenic microbes, and non-pathogenic strains may become pathogenic.
The surveillance of domestic and foreign authors showed that the acquisition of microbial resistance to antibiotics is accompanied by significant changes in their morphology and physiology.
The infection from resistant staphylococci, is much greater than the disease, caused by sensitive to antibiotics strains. Antibiotic resistant Staphylococcus longer linger in the internal organs and can cause long hard proceeding process.
In recent decades in Western Europe and the USA, described a large number of outbreaks of staphylococcal infections in medical institutions with involvement of the majority of the patients were there.
Williams R. in 1959 reported 32 staphylococcal epidemics in maternity hospitals and 75 outbreaks in the surgical wards. In the message of public health services of England in 1965, the analysis of staphylococcal epidemics in 21 therapeutic Department. In the infectious departments catches up to 35%, in therapeutic - 33%, in surgical - 30%, for children - 22% of all patients. Infection most often occurs from the media.
In the offices, where systematic antibiotic treatment, the percentage of native antibiotic-resistant staphylococci, consequently, the number of infected patients is significantly higher.
The duration of hospital stay is an important factor causing the infection. In patients after a stay in surgical clinics aureus was detected twice as often as in the receipt. Most disease occurs in the hospital, some after discharge, sometimes discharged infect the house of staphylococcal infections of others. In England, according to M. Barber at the II International Congress of infectious diseases, children's hospital became the centers penicillinonline strains of staphylococci.
Often in maternity hospitals are observed epidemic outbreaks with significant morbidity of newborns and very high mortality. It takes so threatening that some foreign authors even propose to refuse from maternity hospitals and deliver babies at home.
The infection usually comes from a healthy carriers of aureus, a percentage which among medical workers sometimes reaches 70%. The main reservoir of pathogenic Staphylococcus holders is the nasal cavity.
The mechanism of development of staphylococcal diseases is very difficult. This is due, firstly, the extreme diversity of the biological characteristics of agent (the degree of virulence, toxicogenomic, enzymatic ability), and, second, the nature of protective reactions of the organism (production of antibodies, cell-mediated reactions, sensitisation and modify the reactivity of the organism). It must be emphasized that in the changed under the influence of antibiotic therapy the body extremely changed as immunobiological reaction of the sick and diverse reactions of microbes.