Fibrinolizin (Fibrinolysinum, synonym: plazmin, thrombolysis) is an enzyme. From the plasma of donor blood or placental serum person by activation of plasminogen trypsin. Enzyme fibrinolizin splits fibrinogen and clots of fibrin.
Applied for the treatment of diseases accompanied by the formation of fresh blood clots (acute thrombophlebitis, thromboembolism of the pulmonary and peripheral arteries, the vessels of the brain, heart). Enter fibrinolizin drip into a vein, previously dissolved in izotonicescom solution of sodium chloride (20 000-40 000 IU per 200 and 400 ml) and necessarily when heparin (10 000-15 000 UNITS). The solution is injected slowly over a 4-5 hour. 1 time per day. After fibrinolizina with heparin begin to impose heparin 40 000-60 000 IU a day for 2-3 days (by indicators of blood coagulation). Then the dose is gradually reduced and go to the reception inside anticoagulants of indirect action (see Anticoagulants).
In peripheral arterial thrombosis and acute thrombophlebitis fibrinolizin impose daily for 5-6 days, in myocardial infarction within 2 days.
Contraindications: hemorrhagic diateza, bleeding, open wounds, ulcers disease stomach and duodenal ulcers, jade, tuberculosis of lungs in acute form of radiation sickness, cancer.
The form of release fibrinolizina: vials containing 20 000, 30 000 and 40 000 ED drugs; enclosed vials of sterile izotoniceski solution of sodium chloride at 200, 300 and 400 ml Stored at a temperature of no higher than 4 degrees. Cm. also Enzymatic preparations.