Fucidin (fuzidieva acid) is an antibiotic obtained from the culture fluid Fusidium coccineum. Fucidin on chemical structure refers to cyclopentadecanone, but has no activity and anti-inflammatory properties hormonal steroids.
Fucidin has marked antibacterial properties against grampolaugitionah (especially Staphylococcus) and some gramotricationah kokkov, and Corynebact. diphtheriae, Clostridium tetani, and other types of clostridia and Mycobact. tuberculosis.
Sensitive fucidin bacteria quickly develop resistance to this antibiotic.
Fucidin widely used for treatment of septic and inflammation caused by staphylococci resistant to penicillin.
Fucidin has relatively low toxicity.
Fucidin out from the body slowly; therefore, some patients after administration of per os one dose of 500 mg drug you can find antibacterial activity in the blood after 24 hours and more.
With repeated applications 3 times a day 500 mg), its concentration increases (cumulative). Fucidin excreted in the urine, bile and milk, although in low concentrations.
In the application of fucidin per os often have a burning sensation in the stomach and vomiting. These effects can be prevented by eating fucidin tablets covered soluble in gastric juice cover.
In some cases, see also the phenomena of irritable bowel, meteorism, spastic constipation or, on the contrary, diarrhea, accompanied by severe pain in the abdomen.
Cm. also Antibiotics.