Fumagillin - antibiotic having voting amebicide properties; allocated from a special strain of Aspergillus.
Fumagillin - weak monobasic acid with a total formula CN 34 0 7. This purified fumagillin forms colourless crystals with 190-191°,optically active, practically insoluble in water, soluble in chloroform and acetic acid. Fumagillin unstable, rapidly destroyed by the action of sunlight at temperatures above 40 degrees and in alkaline solutions; stable when stored in a dark place at temperature from +2 up to -5 degrees without access of air.
Fumagillin acts amebicide in vitro at concentrations 1 : 10 000 000 - 1 : 15 000 000. With the introduction of per os patients at doses of 5 to 50 mg daily for 5-7 days in most cases there is the release of intestinal parasites. Has a very weak antibacterial properties and does not affect the normal flora of the intestine. Protivooterne properties fumagillin depend on direct action on the organism of the simplest.
Toxicity is very low. The application of high doses (50 mg), which give a good therapeutic effect, there are sometimes dizziness and loss of appetite (without nausea and vomiting). At lower doses (10 mg) some time after the end of treatment may experience a recurrence of amebiasis.
Fumagillin is used for treating patients with amebic dysentery in the dose of 10 mg twice a day for 10-15 days. Sometimes you need to repeat courses.
Fumagillin could also be the effect in the treatment of patients with other parasitic intestinal diseases, caused by various protozoa (lamblia, trichomona etc), but it has no effect on parasites, located in the internal organs (amebic abscess in the liver), as the application of per os practically not absorbed from the gut.
Cm. also Antibiotics.