Gamma globulin

Gamma globulin fraction whey proteins - globulin (antibodies) in the blood containing immune antibodies. Fraction of gamma globulin heterogeneous; currently there are 3 main types of immunoglobulins; Their contents may vary for different diseases.
Gamma-globulin human presence various antiviral and antibacterial antibodies (see) (against viruses, measles, polio, pertussis, bruchkomitsky agglutinin) and antivenoms (see) (diphtheria, Staphylococcus, and other), which determines its preventive and therapeutic action.
Preparations of gamma globulin prepared from blood donors or placental blood of healthy women. Produced gamma globulin in the USSR in the form of 10% solution; solvent served 0,85% solution of sodium chloride. Gamma globulin is subjected to the control of sterility, safety and apyrogenicity (lack of ability to cause a temperature increase during the introduction).
The drug gamma globulin is effective immunization. Introduction of gamma globulin creates a temporary passive immunity (see) against a number of infectious diseases. Cm. also Globulins.
Clinical use of gamma globulin. Gamma globulin is used for prophylaxis and treatment of infectious diseases mainly in children. Prevention of measles healthy children at the age from 3 months. up to 4 years (and sick and weakened regardless of age)who had contact with measles injected 1.5 - 3 ml once. Passive immunity lasts for 3-4 weeks.
For the prophylaxis of pertussis and pericolosa gamma globulin is administered to healthy children under the age of 6 months, came into contact with patients. With the medical purpose apply the specific anti-pertussis gamma globulin (2-3 doses and more than 3 ml, with an interval 1-2 days). Gamma globulin, introduced in catarrhal or the beginning of convulsive period, reduces the frequency and severity of cough.
During epidemic outbreaks of diseases caused by adenoviruses (see Adenovirus infection), gamma globulin is used for prophylaxis in children groups (in the dose 0.3 ml per 1 kg of weight of a child) at the earliest possible time from the moment of contact. This reduces the incidence of children and the sick enhances the course of the disease.
For prevention of the epidemic of hepatitis (Botkin's disease) gamma globulin routinely administered to children in nurseries, kindergartens and schools (the first - fourth grades) in the dose of 1 ml of Gamma globulin protects against disease hepatitis within 5-6 months. Children who were in contact with the patient infectious hepatitis, be sure to introduce gamma globulin in the dose of 0.5 ml - up to 3 years, 1 ml, from 3 to 7 years, 2 ml, from 7 to 15 years. Treatment with gamma globulin severe and moderate forms of hepatitis (from 2 to 12 dose to 3 ml) reduces icteric period, restores the function of the liver, reduces the likelihood of complications.
Children who were in contact with sick polio, gamma globulin imposed at the rate of 0.3 ml per 1 kg of weight.
In case of contact with sick with scarlet fever the child impose 3-6 ml of gamma globulin, it makes the disease.
All series placental gamma globulin are characterized by a high titer of flu, paragrapsh and adenovirus antibodies, which can be recommended for the prevention and treatment of acute respiratory infections and pneumonia in children of the first year of life (intramuscularly to 3 ml, in the nasal passages - drops gamma globulin 3 to 4 times a day). Gamma globulin has high stimulating effect, and it is used in the treatment weakened children with chronic inflammatory processes simultaneously with antibiotics, given that long-term administration of antibiotics slows down the production of their own antibodies.
Injection technique of gamma globulin give the baby intramuscularly, usually into the upper outer quadrant of the buttocks. Ampoule with gamma globulin must be pre-inspect the fluid must not contain flakes), then open. Sealed content type in a syringe with a long needle with a wide opening. The injection site disinfected with alcohol. Picking up a thinner needle, put it on the syringe and through it enter gamma globulin. Place of injection grease with iodine.