• Hypoproteinemia
  • Thrombocytopenia
  • Eosinophilia
  • The relationship between the intake of whole cow's milk and expressed iron deficiency anemia in children under the age of 2 years has been long established. The development of anemia was associated with insufficient intake of iron in the infant feeding cow's milk; allow also the possibility inhibitory effect of milk in the process of iron absorption. However, in 1962, Wilson et al. [32]in children with iron deficiency anemia, found in 40% of them positive Kala on guaiacol, and 75%is determined in serum precipitating antibodies to cow milk proteins. A more recent study by the same authors showed that caused by the intake of milk blood loss from faeces was significantly greater in the period of consumption of homogenized milk than using child soy mixture or mixtures based treated with heat method of milk. These data were obtained by the method of introduction into the body's own red blood cells labeled 51Cr [33]. The loss of blood in the feces varied from 0.6 to 10.3 ml per day. The appearance of feces with such losses blood remains unchanged, but radioisotope studies indicate that the amount of blood it is proportional to the amount of consumed milk [34] (see Fig. 5). A retrospective study conducted Gryboski [16]showed that the loss of blood in the feces and hypochromic microcytic anemia occur in all patients with gastrointestinal form of Allergy. In a significant percentage of cases in patients of this group developed colitis, and the blood was so significant that the blood in Calais was visible.
    Significant reduction of blood loss and even its complete cessation many children can be achieved within a few days by replacing concentrated milk pasteurized, but in some cases it is necessary to drastically reduce or avoid consumption of milk in any form. The subsequent introduction in a diet of whole cow's milk quickly leads to a resumption of bleeding. If the bleeding is not massive and blood in the stool is not visible, anemia, usually develops slowly; are weeks or months before it becomes severe. However, there are cases when anemia is developing very rapidly, over a few days or weeks; this is when the combination of two factors: the reduced intake of iron and expressed intestinal bleeding. With little blood loss anemia may not develop if the amount received in the body iron enough, and the increase in the formation of hemoglobin and erythrocytes compensate for blood loss [108]. Treating a patient with iron preparations, without exception milk from the diet leads to partial or temporary restoration of the level of hemoglobin, but not stop the bleeding.
    As already noted, hypochromic microcytic anemia often occurs in children with chronic lung disease caused by the intake of milk, particularly with concomitant pulmonary hemosiderosis [77, 83].
    You should always remember about the possibility of hidden bleeding; according to Wilson et al. [34]they were found in about half of children with iron deficiency anemia who received daily more than 1 liter of homogenized pasteurized cow's milk. It is necessary to consider also the possibility of pulmonary hemorrhage in children with symptoms of respiratory or with the corresponding changes on the radiograph. It should be emphasized that the suspected bleeding should occur in all cases of anaemia unclear etiology a child up to 2 years, receiving every day more than 0.5 liters of milk.