Chronic hepatitis and liver cirrhosis

Chronic hepatitis is a common disease, which is based on a chronic inflammatory process in the liver without severe diffuse structure adjustment of the parenchyma and vascular liver. Such an inflammatory process in connective tissue formations of the liver may occur primarily in response to the intervention of the virus and other damaging agents or secondary - as a reaction to the defeat of hepatocytes. Chronic hepatitis can be completely reversible illness or to progress to cirrhosis.
The term dystrophy liver (hepatosis) are indicated pathological conditions under which primary and leading are dystrophic changes in hepatocytes (primarily muscular dystrophy).
For chronic hepatitis often from the very beginning, along with inflammatory changes expressed dystrophic, necrobiotic processes in hepatocytes.
When dystrophy of the liver at a certain stage of the disease occurs secondary reaction connective tissue formations. This makes the specified distinction between conditional and inspires hepatogastricum include cases in which the primary nature of degenerative changes in the liver cells obvious, as well as a secondary character mezenhimalnymi reaction.
The concept of cirrhosis invested clinical-anatomical General overview of the disease, due to the progressive co-parenchymal and stroma liver and degenerative changes of the liver cells (up to necrosis), nodal their regeneration, diffuse connective tissue and diffuse restructuring parenchymal or vascular system, the liver. Clinical presentation of cirrhosis include chronic diseases, functional disorders of the liver parenchyma and portal hypertension varying degrees.
The term liver fibrosis has only pathological aspect, namely the development of connective tissue as a result of reparative and reactive processes in various diseases of the liver (abscess, necrosis, gum, granulomas and so on).
The transition of chronic hepatitis to cirrhosis occurs gradually, without a clear morphological and clinical boundaries between them. Chronic diffuse progressive hepatitis and cirrhosis of the liver are single stages of the pathological process (apartment houses Suckers, 1946; A. L. Myasnikov, 1956; Y. N. Darkseid, 1963, 1968). Hence justified is a recognition of the unity of their etiology and pathogenesis. Cirrhosis of the liver, however, should not be seen only as the final stage of chronic hepatitis, as to the development of cirrhosis lead and other liver lesions, such as gepatocitami (A. L. Myasnikov, 1956). In addition, with the transition in cirrhosis of liver disease gaining new features - irreversible pathological changes, detection of portal hypertension, new conditions portal-hepatic circulation that distinguish this stage from the previous one.

Syndromes, aggravating for liver cirrhosis

Special discussion deserve syndromes, greatly aggravating the clinical picture of cirrhosis: portal hypertension, liver and portal systemic encephalopathy.