Hyposensitization

Attempts to achieve giposencibilization to food allergens, including milk allergens were undertaken with oral or injectable their introduction; none of the methods has not gained widespread use. Only in some cases were able to achieve reduction expressed sensitivity. In literature there are few data on this issue cannot be considered convincing for practical treatment guidelines [54].

Oral desensitization
In 1905 Finkelstein [55], and later by other authors [56 and 59] reported giposencibilization with oral introduction of cow's milk. However, the number of examined patients in these studies is too small for any serious conclusions.
Method of giposencibilization is gradual daily increasing doses of milk, ranging from a few drops diluted milk to the maximum tolerated dose, which is determined individually. The patient then receives daily set the maximum dose, which are trying to increase every few weeks until, until you reach the desired level.
Experiments on animals showed that repeated oral administration of certain antigens very effectively for the development of immunological resistance [60-63]. But for the people it was not thoroughly investigated at the appropriate level, and the underlying method immunological mechanisms remain poorly studied.

Injecting hyposensitization
Most of allergologists not want to apply this method of giposencibilization with food allergies, although the literature describes subcutaneous administration food extracts with this purpose [64, 65]. The authors of one of the works [66] argue that the effectiveness of this method grew by using the "processed by the enzyme extract, made from a beta glucuronidase, 1,3-cyclohexanedione, preteengalleries, chondroitin sulphate and buffer in certain proportions. Carefully conducted studies using double-blind method is not confirmed data on the effectiveness of the injection giposencibilization with food allergies. Still, some doctors continue to use subcutaneous or intradermal injection of food extracts for "desensitization" or "neutralize" the expected symptoms. We believe that the complete denial of such practices or underestimation of its full potential would be wrong, but I want to emphasize that these methods should be used very carefully, taking into account available scientific evidence. Before making a conclusion about the effectiveness of the procedure, it is necessary to exclude the possibility of a placebo effect. In addition, you should try to find a theoretical substantiation of the observed effect, which could confirm objective data. Logically it is obvious that, if there is the phenomenon of "neutralization" of the symptoms, in the heart of it must be some mechanism amenable to scientific analysis. Up until one or another point of view will not receive its theoretical substantiation, the basic rule of its supporters and opponents must be extreme caution. We believe that currently there is insufficient evidence for assertions about the effectiveness of the injection giposencibilization to treat food allergies; method cannot be recommended for wide use., However, we can only welcome any attempts serious theoretical investigations for confirmation or refutation of data on the effectiveness of this technique.

Sublingual hyposensitization (provocative methods to neutralize the symptoms)
Methods sublingual giposencibilization, as well as injecting their followers. Most of them are among the experienced practitioners using sublingual introduction of food allergens for diagnostics, prevention and treatment of food allergies. All remarks and considerations related to injecting methods, fully apply to the hyoid. It seems to us more important to unite the efforts of specialists in the attempt to answer unanswered questions than seek to vindicate somebody's point of view.