Part hormonal systems in the pathogenesis

Above it was already mentioned that certain hormones in alcoholism act as modulators of catecholamine neurotransmitters. But there are other ways of participation of hormones in the pathogenesis of alcoholism.
So, enhanced by pituitary-adrenal activity at all levels. Emerging on the background of chronic alcohol intoxication condition is largely similar to the state of chronic stress. Increases secretion of ACTH, corticosteroids, and so on, In turn, experimental evidence suggests that in a situation of increasing the secretion of adrenocorticotropic hormone (ACTH) alcohol while able to act as a tranquilizer, reducing the level of ACTH. And these are the prerequisites for yet another link pathogenesis.
The defeat of the pituitary-gonadal system leads to substantial shifts and the most common, and hence, may lead to the formation of pathogenetically significant "vicious circle". In patients with alcoholism men often hypogonadism, impotence, infertility, feminization. As a rule, this is a consequence of chronic alcohol intake, which grossly interferes in the synthesis of sex hormones, shifting the ratio of estrogen/androgens in the direction of estrogen (i.e., female sex hormones). This in itself is a single act of acceptance of alcohol capable of passing whips sexual function, changing her long oppression.
Sexual dysfunction increases with increasing duration of alcoholism, intensification of drinking. In 80% of patients with alcoholism noted impotence and signs of atrophy of the testicles. Together with the deterioration of the sexual status of patients simultaneously fall into ever greater reliance on short-term incentive effects of alcohol. About participation of androgens and estrogens in the formation of experimental alcoholism also testify and results, N. Lakoza with co-authors (1978), obtained in experiments on animals.
When alcohol observed multiple lesions hormonal systems (endocrinopathies)whose interaction is often not possible to set the primary and most important of the endocrine disorders (Vedernikov, 1982).