Hormone therapy is treatment with hormones, bursting discs from animal products or synthetic means.
Applies not only with the defeat of the glands of internal secretion, but when endokrinnoi pathology (for example, insulin with mental illness). In the treatment of endocrine diseases hormone therapy may be substitution, stimulating and inhibiting.
Hormone replacement therapy (HRT shown in partial or complete loss of function of the endocrine glands (for example, in diabetes, edisonova disease and others). As the use of a hormone does not eliminate the defeat of the endocrine glands, hormone therapy are applied consistently. The second condition hormone replacement therapy is to establish optimal dose for each patient. It is also necessary to take into account the patient's reactivity to hormonal drug due to various factors (age, pregnancy , and others) and cumulative properties used hormonal drug.
Stimulating hormone therapy is used to stimulate reduced the functions of the endocrine glands (thyroid-stimulating hormone, hypothyroidism, gonadotropic - by reducing the function of sexual glands).
Inhibitory hormone therapy is used at excessive activity (hyperthyroidism) of a particular cancer. Large doses of sex hormones prescribed in some cases, the treatment of malignant tumors of the prostate and mammary glands and other
In addition endocrine diseases, hormone therapy used and other diseases. Corticosteroids (cortisone, prednisone and others) is widely used in allergic diseases, collagen diseases, ulcerative colitis and other; insulin - in psychiatry; anabolic steroids - for stimulation of protein synthesis when exhaustion of different origin.
Methods hormone treatments and ways of administration. Inside apply hormones, little affected secretion of digestive glands (prednisolone, tireoidin, sinestrol and others). Sublingually (under the tongue) prescribed drugs, is rapidly absorbed by the mucous membrane of the mouth (pregnin, methyltestosterone). Intranasal take adiuretin (preparation of the posterior lobe of the pituitary gland). The most common route of administration of hormones - subcutaneous and intramuscular. If necessary, their quick action is used intravenous method (for example, intravenous insulin in diabetic coma, hydrocortisone - edema stroke when edisonova disease and others).
Extremely convenient for patients with hormonal preparations of prolonged action (for example, a single injection of insulin zinc suspension replaces 2-3 injections of regular insulin and has a substitution effect within 24-30 hours).
Complications may occur in overdose used hormonal drug (high blood pressure overdose of corticosteroids, hypoglycemic shock with an overdose of insulin and other). At lower doses of the drug these symptoms disappear. The second type of complications associated with the oppression of the relevant endocrine cancer in long-term use of hormonal drug, so if it is canceled, there are signs of functional insufficiency cancer (for example, the acute lack of napochechnikov crust with long-term use of corticosteroids and their cancellation). To prevent this complication that gradually reduced doses by the end of the treatment course. Cm. articles on the name of hormones.
Hormone therapy in PediatricsChildren most often apply the following hormones: corticosteroids (prednisone, hydrocortisone, triamcinolone, dexamethasone, dezoksikortikosteron - DOCUMENTARY), tireoidin, adiuretin, insulin, lipokain, anabolic hormones.
Corticosteroids affect all types of metabolism. Be administered to children not only for substitution therapy (for example, when adrenergic-genital syndrome), but also in many other pathological conditions (rheumatism, jade, pneumonia, bronchial asthma, hemorrhagic diathesis, collagen diseases, infections and other). In the case of substitution therapy, the dose of prednisone picked individually. Assign it only in the morning (from 6 to 10 hours.) single session or in two doses with an interval of 3 hours. In the latter case 2/3 dose given in the first reception. For hydrocortisone dose in 5 times more, and the interval between the two methods is equal to 1.5 hours. When changing the drug should be aware that 5 mg prednisolone on the biological effects equivalent to 4 mg of triamcinolone and 0.75 mg dexamethasone.
Contraindications to the use of corticosteroid medication in the evening because of the danger of oppression napochechnikov crust of the child and other complications. In severe childhood infections, pneumonia, bronchial asthma, rapid intervention drugs are also appointed only in the morning in doses of 2-3 times the physiological,- 1-1.5 mg/kg (prednisolone). For suppression of infectious-allergic process, immune reactions of the organism corticosteroid drugs are prescribed in the day to 19 hours. every 3 hours in the dose of 1 to 2 mg/kg (prednisolone), and 2/3 the daily dose given up to 10 hours. When edematous syndrome good therapeutic effect is found with a uniform distribution of hormones during the day. After the swelling is redistribution daily dose hormone (2/3 morning, 1/3 dose after lunch). After the weakening of the inflammatory process dose gradually reduced. First cancelled night dose, then a day and more slowly morning. In some diseases in the period of partial remission spend intermittent treatment. With this purpose it is expedient every 2 hours in the morning to give two physiological doses, i.e. 0.8 mg/kg prednisolone. The duration of this course is different (sometimes within 2 years).