Changes in hemodynamics

A sharp pain and disrupting the regulatory functions of the Central nervous system primarily affects the activity of vasomotor centers. Excitation vasomotor center and entered into blood, as a response to painful stimuli, the increased amount of adrenaline cause a spasm of the blood vessels, which leads to increased blood pressure.
The current release of blood from the depot and the flow of fluid from the tissues in the bloodstream, celebrated by many authors, undoubtedly contribute to a sharp increase of arterial blood pressure and, in addition, partly cause of the observed during this period, short-term (30-60 minutes) blood-thinning.
This is followed by dilation of blood vessels (especially peripheral), stasis and Deposit them in the blood. Increases permeability of vascular walls, which is accompanied by vihodnie huge number of (sometimes up to 50% and more from total volume of blood) liquid part of blood into the surrounding tissue. The increased capillary permeability, obviously, is characteristic of the whole body burned. So, we have found a vast accumulation of serous fluid in intermuscular loose tissue breast and pelvic limbs with extensive severe burns back, waist, chest and abdominal wall in horses and cattle in case of their death or slaughter within 7-15 days after burn. Vpotevanie of blood vessels of a large number of plasma leads to thickening of the blood. Increased coagulation and its viscosity and slows down the speed of blood flow. Decreases blood pressure . Slowing ROHE. Increases the number of red blood cells and the percentage of hemoglobin. While in animals with extensive and deep burns, there is often a mismatch between the increase in the number of red blood cells and the percentage of hemoglobin (the increase in the number of red blood cells is relatively small at that time, as a percentage of hemoglobin increases up to 100-140% and more), explain the significant destruction of erythrocytes under the influence of high temperature, and later - formed toxic substances. Hemolysis is sometimes so great that came out of the stroma hemoglobin stains the plasma in pink (lacquer blood). Staining serum in pink and even in the rose-red color us was observed in horses within 1-2 days. after a severe burn. Released hemoglobin provided mainly kidneys, which explains found in these cases sharply expressed hemoglobinuria with a relatively small amount of urine red blood cells and kidney cells of the epithelium. Maximum development of hemoconcentration reaches 2-3 days. after the defeat. Developing blood clots is relative and is mainly a consequence of the loss of a huge number of plasma, as, according to some authors, with extensive burns, as a rule, there is an oppression gemopoaiza.
In addition to increasing the number of red blood cells very quickly and dramatically increases the number of leukocytes, reaching 25,000 or 50,000 cells in 1 mm3 blood. Developing leukocytosis, according to A. A. Spiridonova E. A. Mironov and A. M. Javadyan, is due to the absolute and relative increase of neutrophils. Is neutrophilic shift to the left. Sharply reduced the number of eosinophils, and in severe cases, they almost disappear. Appear cells with degenerative forms of toxic fraction and vacuolization, which can be explained by intoxication leikopoeticescoe system absorbing protein products of disintegration.