Chemical substances blastomogenic

A number of specific substances belonging to different classes of chemical compounds that can cause cancer and other malignant and benign tumors (see Carcinogenic substances).
Blastomogenic substance in terms of experience, you can enter the animals in different ways. The most accepted the introduction into the skin, through the mouth, blurring of the skin. It is also possible introduction intratracheal, intravenous and directly into the fabric of various organs. Blastomogenic substances in experiments impose dissolved in vegetable oils, animal fats, and for lubrication with skin - in benzene, acetone, ether, etc.,
Blastomogenic hydrocarbons can cause tumors in the place of their introduction - sarcoma in a subcutaneous (Fig. 13), papillomavirus and cancer for lubrication of the skin (Fig. 14 and 15), lung cancer when intratracheal administration (Fig. 16 and 17), cancer rumen when introduced into its cavity or wall. In addition, with the introduction of these substances are observed and distant tumor - away from the site of injection, such as lung adenomas (Fig. 18 and 19), adenocarcinoma of the breast, prostate adenoma of the sebaceous glands and other Appearance of such tumors can be explained by the circulation blastomogenic hydrocarbons in the organism, in particular the spread them in the ways of fat metabolism. This circulation is proved spectral fluorescence studies.

Fig. 13. Sarcoma of soft tissues of the rat.
Fig. 14. Papilloma of rat skin in the long-term lubrication of carcinogenic hydrocarbons.
The robed. 15. Skin cancer mouse 6 months after a single application of potent carcinogenic hydrocarbons.
Fig. 16. Experimental lung cancer caused by rats intratracheal the introduction of carcinogenic hydrocarbons.
Fig. 17. Experimental squamous orogovevshi lung cancer skirsnio of character in rats.
Fig. 18. Multiple adenomatous tumors of the lung mouse in the lubrication of coal tar.
Fig. 19. Adenoma of the lungs mouse caused by carcinogenic hydrocarbons.
Fig. 20. Papilloma bladder.

Blastomogenic of aminoazotoluene not cause tumors in the place of their application. When introducing them through the mouth, under the skin or by lubricating skin in all cases, there O. liver, and sometimes tumors of the bladder (Fig. 20) and lungs, but never observed skin cancer or stomach. A number of carcinogenic amines, such as beta-naphtylamine, feeding or subcutaneous injection causes in dogs (and people in the occupational hazards) tumors of the bladder, but no tumors at the injection.
Carcinogenic derivatives fluorine and benzidine derivatives, dicyclohexylamine and nitrite cause in rats and mice, as a rule, multiple O. various organs and tissues as at the injection site, and so far from it - in the skin, milk and sebaceous glands, liver, lungs, kidneys, urinary bladder, intestines, and so on, Some bifluoride cause tumors glandular stomach and intestines.
Of particular interest is a kind of blastomogenic the number of nitrosamines. These substances are relatively simple structure can cause O. some internal organs - lungs, esophagus, stomach, liver, kidney, brain, and other
Thus, you can distinguish blastomogenic substance local and distant action. In the latter case may be specific organotropic action, for example in the liver or bladder associated with certain metabolites carcinogenic substances. Under the action of some carcinogenic substances Acting in the place of their introduction, you can also observe distant multiple tumors of various organs and tissues, resulting from the transfer of these substances on the organism. An important role can play the functional state of the tissue.
Along with an extensive study regarding specific blastomogenic substances was found that the introduction into the skin of rats even such a chemically inert products, such as plastics (for example, cellophane), can cause sarcoma. Lesions appear only with the introduction of the plate, not crushed material or powder. The occurrence of tumors in this case is associated with a physical condition introduced a foreign body and its form. However, histochemical study showed that "plastic blastomogenic" in many respects similar to the process of sarcomas occur at the injection site such known chemical carcinogens, as hydrocarbons.
Introduction into the fabric blastomogenic substances, as any foreign body, immediate causes an inflammatory response. However, the action blastomogenic substances dramatically alter the character and course of this reaction, distorting, tightening her, and partly braking and suppressing; it does not normal scarring, interstitial substance (collagen) and cells in inflammation be undifferentiated, atypical. Inflammatory reaction at action of carcinogenic substances can be expressed little. At occurrence of so-called remote tumors induced by carcinogens, and particularly when there are many dishormonal tumors (see below) inflammation is not observed. It is not a necessary link in the chain of events leading to cancer; it cannot be considered precancerous process.
Under the action of several carcinogenic substances can occur summation of their influence on the organism. In addition, in some cases, there may be potentiation, i.e. the strengthening of the action of carcinogenic substances under the influence of non-cancer or very weakly carcinogenic agents. Such a phenomenon has received the name of counteragent. The most famous example cocarcinogenic effect is the development of skin tumors in mice as a result of one or only a few lubricating carcinogenic hydrocarbons, followed by multiple applications Croton oil.
In the implementation of the effect of blastomogenic substances important role is played by the condition of the body on which they operate, and first of all the state governing nervous, endocrine, metabolic, and so on, in other words, the effect blastomogenic substances is largely determined by endogenous factors.