Cholecystokinin - the hormone that causes the reduction and gallbladder emptying and relaxation of the sphincter of Oddi. Opened in 1928, Ivey and Goldberga (AS Ivy, that is, Oldberg) in experiments cross blood circulation in dogs.
On its biochemical properties of cholecystokinin refers to the polypeptides. Closely related to sekretnom, in contrast to whom no effect on high blood pressure. Formed in the mucosa of the duodenum and the upper section of thin intestines under the influence of fat and protein substances(animal and vegetable oils, egg yolks, meat products), mineral salts (magnesium sulphate, carlsbad salt). Soaked in blood, comes to the gall bladder, putting him above the action.
Different foods cause the formation of different amounts of cholecystokinin, and are determined by the force of Tzimtzum and the degree of gallbladder emptying. Substances, which are called bile, are generated through cholecystokinin. On the level cholecystokinin affects the stomach-quick evacuation of its content, acidity gastric juice, state of the upper section of the small intestine and gallbladder.
Received in 1954 and highly persistent drug cholecystokinin - Sesekin injected in the amount of 3 mg in 10 ml of physiological solution (at the rate of 0.04 mg per 1 kg of body weight of the patient). The reduction and gallbladder emptying begins with the first minutes after the introduction Sesekin and ends in 20-30 min Sesekin enhances contrast study; by providing a standard stimulus, gives an objective assessment of the motor function of the gallbladder. By x-ray . Sesekin allows to determine the anatomical and functional state of the duodenum.