Treatment with enzymes


Modern medicine is increasingly making use of the achievements of biological and medical chemistry in General and of the doctrine of enzymes (Enzymology) in particular.
We bring to attention of the reader to the monograph by M. wolf and K. Ransberger devoted to the problem of use of enzymes in medical practice. It in no way can be considered neither as a first monograph on this issue nor an exhaustive review of the vast literature that exists on this issue. Soviet medical community is well-known works of Russian scientists, devoted to biological and medical application of enzymes in therapy.
In his book, M. wolf and K. Ransberger practically not used the extensive information contained in the publications of Soviet scientists, including those involved with the issue of application of proteolytic enzymes in the clinic *.
Although the monograph called "Treatment"enzymes, it cannot claim to completeness problem therapeutic applications of enzymes in General or proteolytic enzymes in particular. The goal of the authors is to tell the General practice physicians about how and under what conditions can be used as medicine purified preparations of proteolytic enzymes of vegetable or animal origin. This paper presents the results of clinical observation and materials of other authors who worked like M. wolf and K. Ransberger with manufactured in Germany drugs. The main current top of these drugs is artificially composed of a mixture of purified proteolytic enzymes of animal and vegetable origin (trypsin, himotripsin, papain).
M. wolf and K. Ransberger with great enthusiasm describe the results of experimental studies performed on animals who in various ways have introduced these proprietary enzyme preparations, in order to prove the possibility of penetration of proteolytic enzymes in diseased organs and tissues. Clinical observations (made, particularly in Oncology clinics), the authors evaluated with particular enthusiasm, emphasizing the efficacy and safety of treatment of proteolytic enzymes (first of all the above mixtures proteases). However, the authors do not forget to mention that treatment with enzymes should be combined with other modern methods of therapy.
Abandoning strict "academic" style, the authors have managed to write a monograph, which is easy to read with interest. The passion and enthusiasm of the authors transferred to the reader. But, unfortunately, this "looseness" of presentation caused certain disadvantages: not all of the statements or information, supported by precise references to published articles and books, not all information directly related to parse the issues cited and discussed.
It should be noted that the authors, as enthusiasts of this treatment, sometimes to the detriment of objectivity oversimplify the problem. In their statement the efficiency of enzyme therapy, surely exaggerated.
We believe, however, that, despite these shortcomings, the work of M. wolf and K. Ransberger will be of interest to physicians and will bring them some benefit. In our country and abroad are working on the creation of new purified preparations of proteolytic enzymes and various combinations of them. This book contains materials (which are either not published or published in obscure journals), which reflect the accumulated experience of research and clinical application of such drugs produced in Germany. This experience is of particular interest for our doctors, already familiar with the problem in General and prepared for critical evaluation and use of the results of the work and proposals of other authors. The monograph is meant to attract the attention of a wide range of practitioners to effective and promising method of treatment.

* Many of our researchers are generalized in monographies: C. I. Pods, Century A. Grigoryan, V. K. gostishev, S. C. lokhvitskiy, HP Capinski "Proteolytic enzymes in purulent surgery", M, 1970; "problems of medical Enzymology" (edited by C. R. Mordashova), M., 1970; K. N. Veremeenko "Proteolytic enzymes pancreas and their application in the clinic", Kiev, 1967; L. K. Bogush and L. Y. Shvartsman "Application of proteolytic enzymes in the light of tuberculosis", M,. 1970