Changes in the endocrine system and metabolism in the intoxication

It is known that a single injection of alcohol affects the metabolism of sex hormones. There is reduction of the content of the male hormone testosterone in the plasma of blood, especially expressed at high concentrations of alcohol. Hence the impact on sexual function: for example, low doses of alcohol leads to inhibition of the Central nervous system, in the first phase of intoxication like harassed libido. In these conditions, the function of the other hormonal system - pituitary-thyroid complex manifests itself ambiguous, but most of reduced activity. Reduced function of the thyroid gland.
From a physiological point of view, the use of any dose of alcohol (which is becoming an alien substance) is for the body stress. It is proved that the physiological manifestations of organism response to the introduction of ethanol similar response to stress. The fact manifestations of endocrine pattern of stress under the influence of alcohol is not in doubt (Burov, Vedernikov, 1985). At the same time, and the stress caused by intoxication, another factor contributing to the multifaceted biochemical changes 1. There is also a number of violations (such as currency in the tricarboxylic acid cycle)that it is difficult to clearly attributed to the effects of stress, and not-to-action directly ethanol.
For example, in the first hours after drinking alcohol reported symptoms of hyperglycemia (high blood sugar). One of its reasons is the consumption of glycogen during the stress response of the body to excessive exposure to alcohol intoxication. But after that developing hypoglycaemia (low content of glucose in the blood).
It is believed that feeling bad, feeling exhausted after ingestion of significant quantities of alcohol are largely connected with violations of metabolism, leading to acidosis (the shift of the acid-base balance). Cause the release of significant quantities of hydrogen and shifts equilibrium OVER · N-NAD+ and pyruvate-lactate. As a result, in the blood are thrown oxidized metabolites that, apparently, and reduces the ability of the kidneys to eliminate uratov. While excess restored OVER promotes giperprodukcia glycerol and increase fat synthesis. Appearance when drunk hypertriglyceridemia possibly as a result of non-use of free fatty acids as an energy substrate (due to the competition with ethanol).
Excessive amounts of alcohol inhibit the enzymes of mitochondrial respiration and block aerobic oxidation processes (i.e. proceeding with participation of oxygen and the most energetically favorable). This causes the body to adjust to anaerobic metabolism, giving less energy and more non-completely oxidized products.
Thus, obviously intoxicated, even mild, accompanied by marked biochemical changes of the whole organism of the person, in the vast majority of adverse nature. In chronic same alcohol data unfavorable changes accumulate and is irreversible restructuring of the activities of all systems and organs are formed biochemical basis of alcoholism, his pathological substrate.

1. Picture of manifestations of post-stress metabolism complex: the secretion of adrenaline, cortisol, antidiuretic hormone, glucagon can be increased; there is a delay of water and sodium, loss of potassium and acidosis. Catabolised proteins increases, and the synthesis decreases, which complicates post-stress situation in the body. And post-stress energy metabolism characterized by the decrease in the use of glucose lowering effect of insulin, increased lipolysis and ketogenesis.