The calcification

Gipervitaminoz D must be differentiated from the calcification of blood vessels in children of early age. E. B. voit, Century A. Novikov (1967) offer for etiological the basis of all children's vascular calcification of blood vessels to allocate in 4 groups: 1 - metastatic calcification of the arteries, kidney disease; 2 - calcification of the aorta, pulmonary artery disease or coronary artery anomalies of the heart and vessels; 3 - the deposition of calcium in the blood vessels when hypervitaminosis D; 4 - idiopathic group.
Morphological changes of vessels of all these groups of vascular calcification quite similar and are manifested by the deposition of lime in the inner elastic membrane with the simultaneous development of fibrous intimal proliferation of blood vessels. In the literature there is a description of the calcification of soft tissues and blood vessels in neonates and infants with collagen diseases (scleroderma, dermatomyositis), with some congenital diseases (toxoplasmosis, cytomegaly), birth asphyxia (Persianinov, 1961).
E. K. Zhukov and co-authors (1968) believe that calcification in newborns can contribute intravenous administration of hypertonic solutions of calcium chloride, for the latter refers to strong stimuli vascular walls, and in combination with glucose solution, these properties have become even stronger. According to E. K. Zhukova, along with the positive effect of the solutions of calcium chloride and glucose in children, burdened with any pathology, can cause qualitatively different reactions in the form of long spasm. In the tissues and organs receiving power over the vessel, undergo degenerative changes, and necrosis with secondary deposition in them of calcium salts.
Causes of calcification not completely understood. Most of the authors indicate that the development of calcification is a common (humoral, nerve, exchange), and local factors. L. G. Safin (1963) considers this pathological process as inborn suffering associated with intrauterine pathology, involving oxygen with the subsequent accumulation of salts, lime. To the development of calcification also involved a violation of metabolism.
Idiopathic calcinosis vessels should be differentiated from calcification, developing on the ground gipervitaminoza D. this is Usually not difficult, unless there is a history of instructions on the use of child vitamin D, especially in high doses. Congenital calcification is a consequence of the preceding pathological changes in a particular organ. Unlike calcium developed on the soil of hypervitaminosis D, they are not metastatic nature. The calcium concentrated in one body and are not generally in the organs, which are localized lime metastases (the lung, the mucous membrane of the stomach, kidneys and other), which is typical for gipervitaminoza D.
Thus, the problem of calcification in newborns are not yet sufficiently developed for the settlement of the question of differential diagnostics of vascular calcification of different etiology and requires further investigation with participation of pediatricians, obstetricians, biochemists, pathomorphologic.
Renal syndrome in hypervitaminosis D should be differentiated from tubulopatii, a group of diseases and syndromes characterized by the violation of homeostatic functions of the renal tubules. The diseases are genetically determined. First of all it is necessary to differentiate from tubulopatii, manifested as skeletal anomalies, and tubulopatii, proceeding with nephrolithiasis.