Clinic of a poisoning with poison of karakotov

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The bites of poisonous spiders cause acute poisoning characterized by the diversity of manifestations. The degree of intoxication depends on the number entered poison, time of year and other
P. I. Marikovsky (1956), criticizing the methods of research of Coberta, A. S. Shcherbina, K. N. Rosikova, S. C. Constancia, found that the spiders 2 the age of the toxicity of the poison very small due to the small size of the glands and low number of secret; in prepodavatelem the age and in the first period of the life of Mature females toxicity her venom high before death females it is slightly reduced. In the 5th age toxicity poison increases in 3 times in comparison with 2nd and 4th age, in the 8th - 7 times compared with the 6-m; the highest toxicity poison is noted in the 9th, Mature age, in the period of migration and copulation; when migration is complete, and laying one cocoon toxicity poison does not change, after the laying 2 cocoons it is reduced in 2 times and stored in a period of decay females. Much less toxic poison males. Thus, the minimum lethal dose of poison Mature male 160 times higher than that of Mature females; toxicity poison Mature male even slightly inferior to poison females 4-th age.
P. I. Marikovsky (1956) notes the common chemical structure and the similarity of the main clinical manifestations of a poisoning with poison spider Latrodectus living in North and South America, Australia, Africa, the Philippines.
Vellard (1956) noted some differences in the clinic poisoning poisons different species of tarantulas. Change of a chemical reaction poison (summer - alkali, in the autumn and early winter acid), according to Vellard (1956), does not affect its toxicity. This was confirmed Wiener (1956) in the study of poison Lat. hasselti. Sensitivity to poison does not depend on changes in acid-base balance. Cooling or overheating, apparently, beyond the optimum temperature at which the activity of enzymes is set in the mechanism of detoxication of the poison. The higher the toxicity of poison Lat. mactans noted in November, the lowest - in April, may (Keegan E. a., 1962). In the study of the venom of the Latrodectus, starving during the week and kept in the dark at room temperature recorded in vitro increase its toxicity in 2 times. If the serial number of bites in one experiment has been a visible decrease of toxicity of poison on the 5th mumps, and in another experience the most severe poisoning was the 3rd pigs, then the 2-nd and less heavy - at the 1st. P. I. Marikovsky explains this behavior spiders, exposure times, economical expenditure of poison. Pressed spider to production increases contractile ability of the glands and the amount of poison. Therefore, the first experience when you bite 5th lay poison or not extracted, or are highlighted in a small number, and the second goblins bites caused severe poisoning, indicating that the control over the extraction of the poison, and that the sting - the reflex act.
It is believed that children heavier than adults, and women harder than men to carry the bite of the black widow, with children often die (P. I. Marikovsky, 1956). According to I. A. Grateful (1956), poisoning) in children and adults on the severity of the same; among the 12 cases bite of children aged from 1 year to 12 years there were no lethal outcomes in women and men, according to our observations, the difference in degree of poisoning were observed. Pregnant poisoning passed in different ways: in one case (6-month pregnancy) it led to miscarriage, and the other (5 months) resulted in symptoms threatening abortion, but the next day cramping pain stopped, and a pregnant woman was discharged in satisfactory condition (I. A. Grateful, 1956).
Bites produced in the day time, usually localized in the lower leg (25,5%), forearm and trunk (on 16,4%), at night - mostly on the torso (21%), hips (20,2%) and shoulders (17,3%); on the neck and head, respectively 7.4% and 3.7% (I. A. Grateful, 1956).